{"id":2308,"date":"2026-04-08T14:32:00","date_gmt":"2026-04-08T18:32:00","guid":{"rendered":"https:\/\/openintegrative.com\/blog\/?p=2308"},"modified":"2026-06-21T12:56:15","modified_gmt":"2026-06-21T16:56:15","slug":"advanced-glycation-end-products-chronic-disease","status":"publish","type":"post","link":"https:\/\/openintegrative.com\/blog\/advanced-glycation-end-products-chronic-disease\/","title":{"rendered":"Advanced Glycation End Products &amp; Chronic Disease"},"content":{"rendered":"\n<h2 id=\"h-key-takeaways\" class=\"wp-block-heading\"><strong>Key Takeaways<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>AGEs form when sugar sticks to proteins, fats or DNA and changes tissue over time.<\/li>\n\n\n\n<li>High blood sugar raises glycation and puts more strain on blood vessels, kidneys and nerves.<\/li>\n\n\n\n<li>Burnt food and heavily browned food can add more AGEs to the daily diet.<\/li>\n\n\n\n<li>Human trials show low AGE diets can improve fasting insulin and insulin resistance.<\/li>\n\n\n\n<li>Lower sugar intake and gentler cooking can reduce AGE exposure without special products.<\/li>\n<\/ul>\n\n\n\n<h2 id=\"h-age-formation\" class=\"wp-block-heading\"><strong>AGE Formation<\/strong><\/h2>\n\n\n\n<h3 id=\"h-sugar-sticks-to-tissue\" class=\"wp-block-heading\">Sugar Sticks To Tissue<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Advanced glycation end products form when sugar sticks to proteins, fats or DNA. This can happen during normal life. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">High blood sugar makes it happen more often because more sugar stays in the blood and tissues.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Collagen is one of the main targets. It gives shape and strength to skin, tendons, blood vessels and kidneys. When sugar damages collagen, the tissue can become stiffer.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">AGEs can form inside the body. They can also come from food. A 2024 review links AGEs with oxidative stress, inflammation, tissue injury and chronic disease pathways (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38705931\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">1<\/a>).<\/p>\n\n\n\n<h3 id=\"h-tissue-gets-stiffer\" class=\"wp-block-heading\">Tissue Gets Stiffer<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Skin can show glycation earlier than deeper tissue. Skin loses some of its normal stretch and can look older. Blood vessels can also lose some of their normal stretch.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Stiff blood vessels do not respond as well to pressure. Kidneys also depend on healthy structure because they filter blood all day. Nerves need small blood vessels to bring oxygen and nutrients.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This damage can grow slowly. A person may feel fine while blood sugar swings and tissue stress rise. HbA1c gives one clue because it measures sugar attached to hemoglobin.<\/p>\n\n\n\n<h3 id=\"h-cell-stress\" class=\"wp-block-heading\">Cell Stress<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">AGEs can bind to a receptor called RAGE. This can raise inflammation inside cells. It can also increase oxidative stress in blood vessels and immune tissue.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">RAGE appears often in research on diabetes, kidney disease, blood vessel disease and aging. It does not explain every illness by itself. Blood sugar, sleep, stress, food quality and repair all change the final result.<\/p>\n\n\n\n<h2 id=\"h-chronic-disease-links\" class=\"wp-block-heading\"><strong>Chronic Disease Links<\/strong><\/h2>\n\n\n\n<h3 id=\"h-diabetes-amp-insulin-resistance\" class=\"wp-block-heading\">Diabetes &amp; Insulin Resistance<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Diabetes has the clearest link with AGEs. High blood sugar gives glycation more fuel. More glycation can then add more stress to insulin signaling.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This can become a bad loop. Blood sugar rises. Tissue damage rises. Insulin works less well.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A review of randomized trials found that dietary AGEs may affect inflammation, oxidative stress and insulin resistance markers (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26938557\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">2<\/a>). <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A later review found low AGE diets improved insulin resistance and fasting insulin in controlled trials (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33253361\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">3<\/a>).<\/p>\n\n\n\n<h3 id=\"h-blood-vessel-damage\" class=\"wp-block-heading\">Blood Vessel Damage<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Blood vessels need flexible walls and calm signals. AGEs can stiffen vessel walls. They can also irritate the thin lining inside arteries.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Heart disease should not be reduced to cholesterol fear. Cholesterol supports cell structure, hormones, repair and immune defense. Glycation points to damaged proteins, oxidative stress and stiff tissue.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A controlled trial found that a low AGE diet improved insulin sensitivity in overweight adults without body weight change (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27030534\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">4<\/a>). That result is useful because weight loss did not explain the change.<\/p>\n\n\n\n<h3 id=\"h-kidneys-amp-nerves\" class=\"wp-block-heading\">Kidneys &amp; Nerves<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Kidneys filter waste from blood. When kidney function drops, the body may clear fewer glycation byproducts. A higher AGE load can then add more stress to kidney tissue.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Nerves need steady blood flow from small vessels. Glycation can damage those vessels and raise stress around nerve tissue. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This is one reason AGE research often connects with diabetic nerve and kidney damage.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The damage is slow. It can begin with high glucose and continue through poor circulation, inflammation and weak repair.<\/p>\n\n\n\n<h2 id=\"h-main-drivers\" class=\"wp-block-heading\"><strong>Main Drivers<\/strong><\/h2>\n\n\n\n<h3 id=\"h-blood-sugar-load\" class=\"wp-block-heading\">Blood Sugar Load<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">High glucose gives glycation more raw material. Refined starch and sugar can raise glucose beyond what the body handles well. Frequent eating can keep that pressure active for more hours.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Fructose deserves care because it can feed reactive sugar byproducts. Sweet drinks and syrups are common sources. They also make sugar easy to consume without real fullness.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Lower carbohydrate intake can reduce glucose swings for many people. The useful target is steadier blood sugar with less insulin demand. High sugar diets create poor conditions for long term tissue health.<\/p>\n\n\n\n<h3 id=\"h-processed-food\" class=\"wp-block-heading\">Processed Food<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Ultra processed food often brings sugar, refined starch and seed oils together. It can also be heated hard during processing. This gives the body several problems at once.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Fortified grain foods are a poor answer. Synthetic nutrients do not fix refined starch. Fortification can make a weak food look useful while the blood sugar problem remains.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Use whole, traditional and natural meals as the base. One clear example is slow cooked beef with its own fat. This gives protein and minerals without refined grain, seed oil or sweet sauce.<\/p>\n\n\n\n<h3 id=\"h-cooking-heat\" class=\"wp-block-heading\">Cooking Heat<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Cooking changes AGE levels in food. Dry heat and heavy browning create more AGEs than moist cooking at lower heat. Burnt surfaces add chemical stress without adding useful nutrition.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Uribarri and colleagues reported that moist heat, shorter cooking time and lower temperature reduced AGE formation in food (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20497781\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">5<\/a>). This gives a direct kitchen change without special products.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Meat does not need fear. Burnt crusts and blackened surfaces should not become daily habits. Gently cooked meat keeps the nutrition while lowering heat damage.<\/p>\n\n\n\n<h2 id=\"h-lower-age-load\" class=\"wp-block-heading\"><strong>Lower AGE Load<\/strong><\/h2>\n\n\n\n<h3 id=\"h-meal-rhythm\" class=\"wp-block-heading\">Meal Rhythm<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">One or two solid meals can give longer breaks from glucose traffic. Constant snacking keeps insulin and blood sugar active for more hours. The body gets less time away from fuel handling.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Late eating can also hurt the repair time during sleep. Poor sleep worsens glucose control the next day. Better sleep and fewer eating windows can lower glycation.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A four week trial in overweight women found that a low AGE diet improved insulin sensitivity compared with a high AGE diet (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24356597\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">6<\/a>). <\/p>\n\n\n\n<h3 id=\"h-cooking-changes\" class=\"wp-block-heading\">Cooking Changes<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Use moisture more often. Use lower heat. Avoid blackened surfaces.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">These changes do not make food bland. Butter, ghee and tallow can keep meals satisfying without seed oils or sweet marinades. Salt and simple herbs can add flavor without sugar based sauces.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Longer cooking with moisture works well for tougher cuts. It can improve texture while reducing harsh browning. This works well for beef, lamb and other slow cooked meat.<\/p>\n\n\n\n<h3 id=\"h-evidence-limits\" class=\"wp-block-heading\">Evidence Limits<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The evidence is useful, but it has limits. Many human trials are small. AGE measurement is difficult because heat, water, cooking time and browning all change the final amount.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Food lists can also mislead. The same food can have a different <a href=\"https:\/\/openintegrative.com\/blog\/glycation-sugar-stiffens-arteries\/\" type=\"post\" id=\"1178\">AGE<\/a> level after a different cooking method. A hard sear and a moist slow cook give different exposure.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A review of low AGE diet trials in diabetes found possible improvements in glucose markers, inflammation and lipid markers, while also calling for stronger trials (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39518960\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">7<\/a>).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>For any health concerns or questions about a medical condition, get guidance from a physician or another appropriately trained clinician. 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           .oi-sp-recent .oi-sp-grid,\n                .oi-sp-trending .oi-sp-grid {\n                    grid-template-columns: 1fr !important;\n                }\n\n                .oi-sp-top .oi-sp-grid {\n                    display: flex !important;\n                    flex-direction: column !important;\n                }\n\n                .oi-sp-heading {\n                    font-size: 1.2rem !important;\n                }\n            }\n        <\/style><section class=\"oi-sp oi-sp-smart\" data-oi-sp-mode=\"smart\" aria-label=\"Suggested Posts\"><h2 class=\"oi-sp-heading\">Suggested Posts<\/h2><div class=\"oi-sp-grid\"><a class=\"oi-sp-card oi-sp-card-smart\" href=\"https:\/\/openintegrative.com\/blog\/glycation-sugar-stiffens-arteries\/\"><div class=\"oi-sp-thumb\"><img decoding=\"async\" width=\"600\" height=\"600\" data-src=\"https:\/\/openintegrative.com\/blog\/wp-content\/uploads\/2026\/04\/glycation-.webp\" class=\"attachment-medium_large size-medium_large wp-post-image lazyload\" alt=\"\" data-srcset=\"https:\/\/openintegrative.com\/blog\/wp-content\/uploads\/2026\/04\/glycation-.webp 600w, https:\/\/openintegrative.com\/blog\/wp-content\/uploads\/2026\/04\/glycation--300x300.webp 300w, https:\/\/openintegrative.com\/blog\/wp-content\/uploads\/2026\/04\/glycation--150x150.webp 150w\" data-sizes=\"auto, (max-width: 600px) 100vw, 600px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 600px; --smush-placeholder-aspect-ratio: 600\/600;\" \/><\/div><div class=\"oi-sp-body\"><div class=\"oi-sp-title\">Glycation: How Sugar Stiffens Arteries<\/div><div class=\"oi-sp-excerpt\">Key Takeaways Glycation binds sugar to proteins in your arteries Cross links make arteries thick, stiff, and less...<\/div><div class=\"oi-sp-read\">Read More<\/div><\/div><\/a><a class=\"oi-sp-card oi-sp-card-smart\" href=\"https:\/\/openintegrative.com\/blog\/what-damages-blood-vessels\/\"><div class=\"oi-sp-thumb\"><img decoding=\"async\" width=\"600\" height=\"600\" data-src=\"https:\/\/openintegrative.com\/blog\/wp-content\/uploads\/2026\/04\/blood-vessels-vein.webp\" class=\"attachment-medium_large size-medium_large wp-post-image lazyload\" alt=\"\" data-srcset=\"https:\/\/openintegrative.com\/blog\/wp-content\/uploads\/2026\/04\/blood-vessels-vein.webp 600w, https:\/\/openintegrative.com\/blog\/wp-content\/uploads\/2026\/04\/blood-vessels-vein-300x300.webp 300w, https:\/\/openintegrative.com\/blog\/wp-content\/uploads\/2026\/04\/blood-vessels-vein-150x150.webp 150w\" data-sizes=\"auto, (max-width: 600px) 100vw, 600px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 600px; --smush-placeholder-aspect-ratio: 600\/600;\" \/><\/div><div class=\"oi-sp-body\"><div class=\"oi-sp-title\">What Damages Blood Vessels &#038; How To Prevent It<\/div><div class=\"oi-sp-excerpt\">Key Takeaways The endothelium is the thin inner lining that protects every blood vessel. High blood sugar, smoking,...<\/div><div class=\"oi-sp-read\">Read More<\/div><\/div><\/a><a class=\"oi-sp-card oi-sp-card-smart\" href=\"https:\/\/openintegrative.com\/blog\/heart-health\/\"><div class=\"oi-sp-thumb\"><img decoding=\"async\" width=\"600\" height=\"600\" data-src=\"https:\/\/openintegrative.com\/blog\/wp-content\/uploads\/2026\/04\/heart_.webp\" class=\"attachment-medium_large size-medium_large wp-post-image lazyload\" alt=\"\" data-srcset=\"https:\/\/openintegrative.com\/blog\/wp-content\/uploads\/2026\/04\/heart_.webp 600w, https:\/\/openintegrative.com\/blog\/wp-content\/uploads\/2026\/04\/heart_-300x300.webp 300w, https:\/\/openintegrative.com\/blog\/wp-content\/uploads\/2026\/04\/heart_-150x150.webp 150w\" data-sizes=\"auto, (max-width: 600px) 100vw, 600px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 600px; --smush-placeholder-aspect-ratio: 600\/600;\" \/><\/div><div class=\"oi-sp-body\"><div class=\"oi-sp-title\">Heart Health Tips For Daily Energy &amp; Wellness<\/div><div class=\"oi-sp-excerpt\">Key Takeaways The heart works without pause, so it needs steady fuel, oxygen, and minerals daily. Heart cells...<\/div><div class=\"oi-sp-read\">Read More<\/div><\/div><\/a><\/div><\/section>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 id=\"h-research\" class=\"wp-block-heading\"><strong>Research<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Zhang, Y. et al. 2024. Advanced Glycation End Products in Disease Development and Prevention. International Journal of Molecular Sciences. PMID 38705931.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Clarke, R.E. et al. 2016. Dietary Advanced Glycation End Products and Risk Factors for Chronic Disease. Nutrients. DOI 10.3390\/nu8030125. PMID 26938557.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Sohouli, M.H. et al. 2021. The Impact of Low Advanced Glycation End Products Diet on Metabolic Risk Factors. Scientific Reports. PMID 33253361.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">de Courten, B. et al. 2016. Diet low in advanced glycation end products increases insulin sensitivity in healthy overweight individuals. The American Journal of Clinical Nutrition. DOI 10.3945\/ajcn.115.125427. PMID 27030534.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Uribarri, J. et al. 2010. Advanced glycation end products in foods and a practical guide to their reduction in the diet. Journal of the American Dietetic Association. DOI 10.1016\/j.jada.2010.03.018. PMID 20497781.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Mark, A.B. et al. 2014. Consumption of a diet low in advanced glycation end products for 4 weeks improves insulin sensitivity in overweight women. Diabetes Care. DOI 10.2337\/dc13-0842. PMID 24356597.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Seyedsadjadi, N. et al. 2024. Effects of a low advanced glycation end products diet on cardiometabolic parameters in diabetes mellitus. Diabetes Research and Clinical Practice. PMID 39518960.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Baye, E. et al. 2017. Consumption of diets with low advanced glycation end products improves cardiometabolic parameters. Scientific Reports. DOI 10.1038\/s41598-017-02268-0.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Prasad, C. et al. 2017. Advanced Glycation End Products and Risks for Chronic Diseases. International Journal of Molecular Sciences. PMID 28621763.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Snelson, M. and Coughlan, M.T. 2019. Dietary Advanced Glycation End Products. Nutrients. PMID 31336765.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Uribarri, J. et al. 2015. Dietary advanced glycation end products and their role in health and disease. Advances in Nutrition. PMID 26178030.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" id=\"h-key-takeaways\">Guilbaud, A. et al. 2016. How Can Diet Affect the Accumulation of Advanced Glycation End Products in the Human Body. Foods. DOI 10.3390\/foods5040084.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Lu, X. et al. (2025) \u2018Effect of dietary intake of advanced glycation end products on biomarkers of type 2 diabetes: a systematic review and meta-analysis\u2019, Critical Reviews in Food Science and Nutrition. Available at: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39320860\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">https:\/\/pubmed.ncbi.nlm.nih.gov\/39320860\/<\/a> <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Zhang, Y. et al. (2025) \u2018Advanced Glycation End Products in Disease: Pathophysiology, Clinical Significance, and Therapeutic Approaches\u2019, Antioxidants, 14(4), p. 492. Available at: <a href=\"https:\/\/www.mdpi.com\/2076-3921\/14\/4\/492\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">https:\/\/www.mdpi.com\/2076-3921\/14\/4\/492<\/a> <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Sharifi-Zahabi, E. et al. (2021) \u2018Circulating Advanced Glycation End Products and Their Soluble Receptors in Relation to All-Cause and Cardiovascular Mortality: A Systematic Review and Meta-analysis of Prospective Observational Studies\u2019, Advances in Nutrition, 12(6), pp. 2157\u20132171. Available at: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34139010\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">https:\/\/pubmed.ncbi.nlm.nih.gov\/34139010\/<\/a> <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Sisay, M. et al. (2020) \u2018The relationship between advanced glycation end products and gestational diabetes: A systematic review and meta-analysis\u2019, PLoS One, 15(10), e0240382. Available at: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33085688\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">https:\/\/pubmed.ncbi.nlm.nih.gov\/33085688\/<\/a> <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Uribarri, J. et al. (2011) \u2018Restriction of advanced glycation end products improves insulin resistance in human type 2 diabetes: potential role of AGER1 and SIRT1\u2019, Diabetes Care, 34(7), pp. 1610\u20131616. Available at: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21709297\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">https:\/\/pubmed.ncbi.nlm.nih.gov\/21709297\/<\/a> <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Vlassara, H. et al. (2016) \u2018Oral AGE restriction ameliorates insulin resistance in obese individuals with the metabolic syndrome: a randomised controlled trial\u2019, Diabetologia, 59(10), pp. 2181\u20132192. Available at: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27468708\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">https:\/\/pubmed.ncbi.nlm.nih.gov\/27468708\/<\/a> (Accessed: 26 March 2026).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Goudarzi, R. et al. (2020) \u2018Low advanced Glycation end product diet improves the central obesity, insulin resistance and inflammatory profiles in Iranian patients with metabolic syndrome: a randomized clinical trial\u2019, Journal of Diabetes and Metabolic Disorders, 19(2), pp. 1129\u20131138. Available at: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33520830\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">https:\/\/pubmed.ncbi.nlm.nih.gov\/33520830\/<\/a> <\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Key Takeaways AGE Formation Sugar Sticks To Tissue Advanced glycation end products form when sugar sticks to proteins, fats or DNA. This can happen during normal life. High blood sugar makes it happen more often because more sugar stays in the blood and tissues. Collagen is one of the main targets. It gives shape and &#8230; <a title=\"Advanced Glycation End Products &amp; Chronic Disease\" class=\"read-more\" href=\"https:\/\/openintegrative.com\/blog\/advanced-glycation-end-products-chronic-disease\/\" aria-label=\"Read more about Advanced Glycation End Products &amp; Chronic Disease\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":2399,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_wpscppro_dont_share_socialmedia":false,"_wpscppro_custom_social_share_image":0,"_facebook_share_type":"default","_twitter_share_type":"default","_linkedin_share_type":"default","_pinterest_share_type":"default","_linkedin_share_type_page":"default","_instagram_share_type":"default","_medium_share_type":"default","_threads_share_type":"default","_google_business_share_type":"default","_selected_social_profile":[],"_wpsp_enable_custom_social_template":false,"_wpsp_social_scheduling":{"enabled":true,"datetime":"2026-04-08 18:32:00","platforms":[],"status":"pending_publication","dateOption":"today","timeOption":"now","customDays":"","customHours":"","customDate":"","customTime":"","schedulingType":"absolute"},"_wpsp_active_default_template":true},"categories":[226,161],"tags":[300,366,312],"class_list":["post-2308","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cardiovascular-health","category-circulation","tag-carbohydrates","tag-glycation","tag-insulin-resistance","no-featured-image-padding"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.9 (Yoast SEO v27.9) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Advanced Glycation End Products &amp; 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