{"id":2551,"date":"2026-04-22T10:23:00","date_gmt":"2026-04-22T14:23:00","guid":{"rendered":"https:\/\/openintegrative.com\/blog\/?p=2551"},"modified":"2026-04-20T04:43:40","modified_gmt":"2026-04-20T08:43:40","slug":"synthetic-b-vitamins-vs-natural-risks","status":"publish","type":"post","link":"https:\/\/openintegrative.com\/blog\/synthetic-b-vitamins-vs-natural-risks\/","title":{"rendered":"Synthetic B Vitamins Vs Natural &amp; Health Risks"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\" id=\"h-key-takeaways\"><strong>Key Takeaways<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Synthetic B vitamins are made in factories, not grown inside real food.<\/li>\n\n\n\n<li>The body can handle synthetic forms differently from food based forms.<\/li>\n\n\n\n<li>Folic acid and cyanocobalamin are not the same as food forms.<\/li>\n\n\n\n<li>Fortified foods can raise synthetic vitamin intake day after day.<\/li>\n\n\n\n<li>Liver, eggs, meat, dairy, and shellfish give B vitamins in food form.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-factory-origins\"><strong>Factory Origins<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-food-vs-factory\">Food vs Factory<\/h3>\n\n\n\n<p>Synthetic B vitamins do not come from liver, eggs, beef, milk, or shellfish. They are made in factories. The process can use fermentation tanks, chemical reactions, purification steps, drying, and stabilizing. That alone makes them different from B vitamins found in food.<\/p>\n\n\n\n<p>Vitamin B12 is often made by growing selected bacteria in large tanks, then pulling the compound out and cleaning it for sale. Riboflavin is also made this way on an industrial scale. Niacin is made with industrial chemistry chosen for cost and output, not for natural food value (<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5282855\/\">Fang et al., 2017<\/a>; <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7693651\/\">Averianova et al., 2020<\/a>; <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8836525\/\">Lisicki et al., 2022<\/a>).<\/p>\n\n\n\n<p>The word vitamin can make these products sound simple and clean. The real story is much harder than that. These are industrial isolates made for shelf life, easy mixing and mass sale.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-why-form-counts\">Why Form Counts<\/h3>\n\n\n\n<p>A label can hide a big difference in form. Food folate is not folic acid. Food B12 is not the same thing as cyanocobalamin. A vitamin name can stay the same while the form changes in ways that affect the body.<\/p>\n\n\n\n<p>The body does not respond to a label word. The body responds to the exact form, the dose, and the meal around it. A meal of eggs or liver brings fat, protein, minerals, cholesterol and many linked compounds at the same time. A synthetic isolate does not bring that same package.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-chemical-production\"><strong>Chemical Production<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-what-the-process-uses\">What The Process Uses<\/h3>\n\n\n\n<p>Some synthetic B vitamins have long industrial histories tied to strong chemical inputs. <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Thiamine has been made through multi step chemical synthesis. <\/li>\n\n\n\n<li>Pyridoxine has also been made through synthetic organic chemistry instead of being taken from food. <\/li>\n\n\n\n<li>Pantothenic acid production has used industrial intermediates.<\/li>\n<\/ul>\n\n\n\n<p>A synthetic vitamin pill is not a food nutrient lifted intact from nature. It is an industrial product built through a manufacturing chain.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-what-that-means\">What That Means<\/h3>\n\n\n\n<p>The hazard record for some common industrial chemicals is plain. Hydrochloric acid is corrosive and can injure the eyes, skin, throat and lungs. Hydrogen cyanide can block oxygen use at the cell level and can lead to rapid collapse in high exposure settings (<a href=\"https:\/\/wwwn.cdc.gov\/TSP\/MMG\/MMGDetails.aspx?mmgid=758&amp;toxid=147\">Centers for Disease Control and Prevention, 2024a<\/a>; <a href=\"https:\/\/www.cdc.gov\/niosh\/ershdb\/emergencyresponsecard_29750038.html\">Centers for Disease Control and Prevention, 2025<\/a>).<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Formaldehyde is a known human carcinogen. <\/li>\n\n\n\n<li>Pyridine can harm the nervous system and may injure the liver and kidneys. <\/li>\n\n\n\n<li>Isobutyraldehyde and propylene glycol also have toxicology records that include irritation and poisoning risk in some settings. <\/li>\n<\/ul>\n\n\n\n<p>None of these belong in any romantic story about nutrition. Factory isolates come from industrial systems, not from real food. <\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-food-forms\"><strong>Food Forms<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-natural-delivery\">Natural Delivery<\/h3>\n\n\n\n<p>Natural B vitamins come inside living tissue. Liver, egg yolks, red meat, dairy and shellfish bring these nutrients with amino acids, fats, trace minerals and the physical structure of food. That package can change how digestion works and how nutrients move into blood and tissue.<\/p>\n\n\n\n<p>A pill or fortified flour cannot copy that. Even when a synthetic vitamin matches one molecule found in nature, the body still meets it in a very different setting. The speed of entry can differ. The partner nutrients are missing. The balance of forms can shift.<\/p>\n\n\n\n<p>This helps explain why many people do better with food first from animal sources. Real food gives a full package. A factory isolate gives one selected compound.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-folate-amp-b12\">Folate &amp; B12<\/h3>\n\n\n\n<p>Folic acid is an oxidized synthetic form. Food folate comes in reduced forms that fit human metabolism more closely. Human studies have found that 5 methyltetrahydrofolate can raise folate markers as well as or better than folic acid while lowering unmetabolized folic acid in blood (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16825690\/\">Lamers et al., 2006<\/a>; <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37649241\/\">Cochrane et al., 2024<\/a>).<\/p>\n\n\n\n<p>Other work found unmetabolized folic acid in serum after intake from fortified foods and supplements. That means the body does not always clear the synthetic form in a smooth way right after intake (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9174474\/\">Kelly et al., 1997<\/a>). That is a real finding, and it weakens the lazy claim that all folate forms are equal.<\/p>\n\n\n\n<p>Vitamin B12 has the same issue. Cyanocobalamin, hydroxocobalamin, methylcobalamin, and adenosylcobalamin are not handled in the same way. Human studies have found differences in blood markers and retention after oral dosing with cyanocobalamin and hydroxocobalamin (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29038891\/\">Greibe et al., 2018<\/a>; <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/4165301\/\">Chalmers and Shinton, 1965<\/a>). Saying B12 is B12 is too crude to be useful.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-health-concerns\"><strong>Health Concerns<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-long-use-questions\">Long Use Questions<\/h3>\n\n\n\n<p>The strongest case against synthetic B vitamins rests on form, dose, and repeated use. Many people get them from more than one source at the same time. Fortified grains, breakfast cereals, drinks, bars, and supplements can all add to the total. That is a real concern with folic acid. Reviews still discuss unmetabolized folic acid, upper intake concerns, and the problem of layered exposure in places where fortification is common (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35807899\/\">Ledowsky et al., 2022<\/a>). Blood levels can rise, yet a higher blood marker does not settle the long term safety question.<\/p>\n\n\n\n<p>Vitamin B6 also deserves caution. High pyridoxine intake has been linked with sensory neuropathy in human reports and later reviews (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37447150\/\">Muhamad et al., 2023<\/a>; <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/1620347\/\">Berger et al., 1992<\/a>). Numbness, tingling, and nerve symptoms are not small side issues. They are clear signs that more is not always better.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-better-sources\">Better Sources<\/h3>\n\n\n\n<p>People who want more B vitamins can start with <a href=\"https:\/\/openintegrative.com\/blog\/natural-vs-synthetic-nutrients-hidden-risks\/\" type=\"post\" id=\"1745\">real food<\/a> instead of isolates. Liver is one of the richest sources. Eggs, beef, lamb, dairy and shellfish also give a broad spread of B vitamins in food form.<\/p>\n\n\n\n<p>A simple meal can do more than a fortified snack. Two eggs with beef at breakfast gives useful B vitamins in a real food package. A serving of liver once or twice a week can cover a lot of ground. Full fat dairy and shellfish can add more, based on tolerance and access. This also fits a high fat animal based way of eating that cuts out seed oils, ultra processed foods and fortified grain products. It keeps nutrient intake close to food and far from factory blending.<\/p>\n\n\n\n<p><em>Before changing your diet, supplements, or health routine, talk with a licensed healthcare professional. For any health concerns or questions about a medical condition, get guidance from a physician or another appropriately trained clinician.<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-faqs\"><strong>FAQs<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-are-synthetic-b-vitamins-the-same-as-natural-b-vitamins\"><strong>Are Synthetic B Vitamins The Same As Natural B Vitamins?<\/strong><\/h3>\n\n\n\n<p>No. They may share a vitamin name, but the source, form, and body handling can differ in important ways.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-why-is-folic-acid-viewed-more-carefully\"><strong>Why Is Folic Acid Viewed More Carefully?<\/strong><\/h3>\n\n\n\n<p>It is a synthetic oxidized form, and studies have found unmetabolized folic acid in blood after fortified foods or supplements.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-does-the-body-treat-all-b12-forms-the-same\"><strong>Does The Body Treat All B12 Forms The Same?<\/strong><\/h3>\n\n\n\n<p>No. Different B12 forms can show different retention and blood marker results after intake.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-which-foods-give-natural-b-vitamins-without-fortification\"><strong>Which Foods Give Natural B Vitamins Without Fortification?<\/strong><\/h3>\n\n\n\n<p>Liver, eggs, red meat, dairy, and shellfish are major sources of natural B vitamins.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-why-avoid-fortified-foods-for-b-vitamins\"><strong>Why Avoid Fortified Foods For B Vitamins?<\/strong><\/h3>\n\n\n\n<p>They add synthetic isolates to processed products and can raise total intake day after day.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-research\"><strong>Research<\/strong><\/h2>\n\n\n\n<p>Fang, H., Kang, J. and Zhang, D. (2017) \u2018<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5282855\/\">Microbial production of vitamin B12: a review and future perspectives<\/a>\u2019, <em>Microbial Cell Factories<\/em>, 16, 15.<\/p>\n\n\n\n<p>Averianova, L.A., Balabanova, L.A., Son, O.M., Podvolotskaya, A.B. and Tekutyeva, L.A. (2020) \u2018<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7693651\/\">Production of Vitamin B2 (Riboflavin) by Microorganisms: An Overview<\/a>\u2019, <em>Frontiers in Bioengineering and Biotechnology<\/em>, 8, 570828.<\/p>\n\n\n\n<p>Lisicki, D., Duda-Madej, A., Patelski, P., Wr\u00f3blewska-\u0141uczka, P. and Wr\u00f3bel, R.J. (2022) \u2018<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8836525\/\">Methods to Produce Nicotinic Acid with Potential Industrial Applications<\/a>\u2019, <em>Molecules<\/em>, 27(4), 1185.<\/p>\n\n\n\n<p>Centers for Disease Control and Prevention (2024a) \u2018<a href=\"https:\/\/wwwn.cdc.gov\/TSP\/MMG\/MMGDetails.aspx?mmgid=758&amp;toxid=147\">Medical Management Guidelines for Hydrogen Chloride<\/a>\u2019.<\/p>\n\n\n\n<p>Centers for Disease Control and Prevention (2025) \u2018<a href=\"https:\/\/www.cdc.gov\/niosh\/ershdb\/emergencyresponsecard_29750038.html\">Hydrogen Cyanide (AC): Systemic Agent<\/a>\u2019, <em>NIOSH Emergency Response Safety and Health Database<\/em>.<\/p>\n\n\n\n<p>Lamers, Y., Prinz-Langenohl, R., Br\u00e4mswig, S. and Pietrzik, K. (2006) \u2018<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16825690\/\">Red blood cell folate concentrations increase more after supplementation with [6S]-5-methyltetrahydrofolate than with folic acid in women of childbearing age<\/a>\u2019, <em>American Journal of Clinical Nutrition<\/em>, 84(1), pp. 156\u2013161.<\/p>\n\n\n\n<p>Cochrane, K.M., Houghton, L.A., Inglis, J.E., Chatterjee, A., Brossard, D., Rioux, F.M., Stabler, S.P. and O\u2019Connor, D.L. (2024) \u2018<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37649241\/\">Supplementation with (6 S)-5-methyltetrahydrofolic acid appears as effective as folic acid in maintaining maternal folate status while reducing unmetabolised folic acid in maternal plasma: a randomised trial of pregnant women in Canada<\/a>\u2019, <em>British Journal of Nutrition<\/em>, 131(1), pp. 92\u2013102.<\/p>\n\n\n\n<p>Kelly, P., McPartlin, J., Goggins, M., Weir, D.G. and Scott, J.M. (1997) \u2018<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9174474\/\">Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements<\/a>\u2019, <em>American Journal of Clinical Nutrition<\/em>, 65(6), pp. 1790\u20131795.<\/p>\n\n\n\n<p>Greibe, E., Nex\u00f8, E. and Hvas, A.M. (2018) \u2018<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29038891\/\">Increase in circulating holotranscobalamin after oral administration of cyanocobalamin or hydroxocobalamin in healthy adults with low and normal cobalamin status<\/a>\u2019, <em>European Journal of Nutrition<\/em>, 57(8), pp. 2847\u20132855.<\/p>\n\n\n\n<p>Chalmers, J.N. and Shinton, N.K. (1965) \u2018<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/4165301\/\">Comparison of hydroxocobalamin and cyanocobalamin in the treatment of pernicious anaemia<\/a>\u2019, <em>Lancet<\/em>, 2(7426), pp. 1305\u20131308.<\/p>\n\n\n\n<p>Ledowsky, C., Hall, B., Castejon, M., Harnett, J. and Cooley, K. (2022) \u2018<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35807899\/\">Women Taking a Folic Acid Supplement in Countries with Mandatory Food Fortification Programs May Be Exceeding the Upper Tolerable Limit of Folic Acid: A Systematic Review<\/a>\u2019, <em>Nutrients<\/em>, 14(13), 2715.<\/p>\n\n\n\n<p>Muhamad, R., Ismail, N.S., Ali, N., Hamzah, N.H., Hamzah, M., Mokhtar, A.M., Baharudin, A., Sidek, N.N.M. and Nadarajah, S. (2023) \u2018<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37447150\/\">The Role of Vitamin B6 in Peripheral Neuropathy: A Systematic Review<\/a>\u2019, <em>Nutrients<\/em>, 15(13), 2823.<\/p>\n\n\n\n<p>Berger, A.R., Schaumburg, H.H., Schroeder, C., Apfel, S. and Reynolds, R. (1992) \u2018<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/1620347\/\">Dose response, coasting, and differential fiber vulnerability in human toxic neuropathy: a prospective study of pyridoxine neurotoxicity<\/a>\u2019, <em>Neurology<\/em>, 42(7), pp. 1367\u20131370.<\/p>\n\n\n\n<p>Zhang, Y., Li, Z., Liu, H. and Zhao, G. (2024) \u2018<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41664455\/\">Thiamine metabolism in microbes and strategies for its biotechnological production<\/a>\u2019, <em>Applied Microbiology and Biotechnology<\/em>.<\/p>\n\n\n\n<p>Centers for Disease Control and Prevention (2024b) \u2018<a href=\"https:\/\/www.cdc.gov\/chemical-emergencies\/chemical-fact-sheets\/ammonia.html\">Ammonia<\/a>\u2019, <em>Chemical Emergencies Fact Sheet<\/em>.<\/p>\n\n\n\n<p>Centers for Disease Control and Prevention (2011) \u2018<a href=\"https:\/\/wwwn.cdc.gov\/TSP\/PHS\/PHS.aspx?phsid=218&amp;toxid=39\">Formaldehyde Public Health Statement<\/a>\u2019, <em>ATSDR Toxic Substance Portal<\/em>.<\/p>\n\n\n\n<p>PubChem (2024a) \u2018<a href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Propylene-Glycol\">Propylene Glycol<\/a>\u2019, <em>National Center for Biotechnology Information<\/em>.<\/p>\n\n\n\n<p>PubChem (2024b) \u2018<a href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/439368\">D-Pantolactone<\/a>\u2019, <em>National Center for Biotechnology Information<\/em>.<\/p>\n\n\n\n<p>Agency for Toxic Substances and Disease Registry (1992) \u2018<a href=\"https:\/\/wwwn.cdc.gov\/TSP\/PHS\/PHS.aspx?phsid=533&amp;toxid=96\">Pyridine Public Health Statement<\/a>\u2019.<\/p>\n\n\n\n<p>National Institute for Occupational Safety and Health (2024) \u2018<a href=\"https:\/\/www.cdc.gov\/niosh\/npg\/npgd0541.html\">Pyridine<\/a>\u2019, <em>NIOSH Pocket Guide to Chemical Hazards<\/em>.<\/p>\n\n\n\n<p>New Jersey Department of Health (n.d.) \u2018<a href=\"https:\/\/www.nj.gov\/health\/eoh\/rtkweb\/documents\/fs\/1051.pdf\">Isobutyraldehyde Hazard Summary<\/a>\u2019.<\/p>\n\n\n\n<p>Henderson, A.M., Aleliw, M., Teo, T.H., Kinnear, B., Choi, E., Taba, N., Croxford, R., Dary, O., Allen, L.H., Green, T.J. and Khor, G.L. (2018) \u2018<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29878267\/\">l-5-Methyltetrahydrofolate supplementation increases blood folate concentrations to a greater extent than folic acid supplementation in Malaysian women<\/a>\u2019, <em>Journal of Nutrition<\/em>, 148(6), pp. 855\u2013862.<\/p>\n\n\n\n<p>Obeid, R., Munz, W. and Herrmann, W. (2012) \u2018<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22746304\/\">The emerging role of unmetabolized folic acid in human diseases: myth or reality?<\/a>\u2019, <em>Current Drug Metabolism<\/em>, 13(8), pp. 1184\u20131195.<\/p>\n\n\n\n<p>Field, M.S. and Stover, P.J. (2018) \u2018<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29155442\/\">Safety of folic acid<\/a>\u2019, <em>Annals of the New York Academy of Sciences<\/em>, 1414(1), pp. 59\u201371.<\/p>\n\n\n\n<p>Hoffer, L.J., Robitaille, L., Elian, K.M., Triptiany, P., Mamer, O.A. and Reimer, M.L. (2005) \u2018<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16154437\/\">Comparative effects of hydroxocobalamin and cyanocobalamin on plasma homocysteine concentrations in end-stage renal disease<\/a>\u2019, <em>Clinical Chemistry<\/em>, 51(10), pp. 1922\u20131924.<\/p>\n\n\n\n<p>Ohrvik, V.E. and Witth\u00f6ft, C.M. (2011) \u2018<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22254106\/\">Human folate bioavailability<\/a>\u2019, <em>Nutrients<\/em>, 3(4), pp. 475\u2013490.<\/p>\n\n\n\n<p>McNulty, H. and Pentieva, K. (2004) \u2018<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15831124\/\">Folate bioavailability<\/a>\u2019, <em>Proceedings of the Nutrition Society<\/em>, 63(4), pp. 529\u2013536.<\/p>\n\n\n\n<p>Choi, J.-H., Yates, Z., Veysey, M., Heo, Y.-R. and Lucock, M. (2014) \u2018<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25580388\/\">Contemporary issues surrounding folic Acid fortification initiatives<\/a>\u2019, <em>Preventive Nutrition and Food Science<\/em>, 19(4), pp. 247\u2013260.<\/p>\n\n\n\n<p>Centers for Disease Control and Prevention (n.d.) \u2018<a href=\"https:\/\/archive.cdc.gov\/www_atsdr_cdc_gov\/formaldehyde\/index.html\">Formaldehyde and Your Health<\/a>\u2019, archived ATSDR page.<\/p>\n\n\n\n<p>Centers for Disease Control and Prevention (n.d.) \u2018<a href=\"https:\/\/wwwn.cdc.gov\/Tsp\/MMG\/MMGDetails.aspx?mmgid=216&amp;toxid=39\">Medical Management Guidelines for Formaldehyde<\/a>\u2019.<\/p>\n\n\n\n<p>Centers for Disease Control and Prevention (n.d.) \u2018<a href=\"https:\/\/wwwn.cdc.gov\/TSP\/MMG\/MMGDetails.aspx?mmgid=1141&amp;toxid=249\">Medical Management Guidelines for Hydrogen Cyanide<\/a>\u2019.<\/p>\n\n\n\n<p>Centers for Disease Control and Prevention (n.d.) \u2018<a href=\"https:\/\/www.cdc.gov\/niosh\/idlh\/74908.html\">Hydrogen cyanide<\/a>\u2019, <em>NIOSH IDLH<\/em>.<\/p>\n\n\n\n<p>Environmental Protection Agency (2000) \u2018<a href=\"https:\/\/www.epa.gov\/sites\/default\/files\/2016-09\/documents\/hydrochloric-acid.pdf\">Hydrochloric Acid (Hydrogen Chloride) Hazard Summary<\/a>\u2019.<\/p>\n\n\n\n<p>National Cancer Institute (2011) \u2018<a href=\"https:\/\/www.cancer.gov\/about-cancer\/causes-prevention\/risk\/substances\/formaldehyde\/formaldehyde-fact-sheet\">Formaldehyde and Cancer Risk<\/a>\u2019.<\/p>\n\n\n\n<p>National Center for Biotechnology Information (n.d.) \u2018<a href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Isobutyraldehyde\">Isobutyraldehyde<\/a>\u2019, <em>PubChem<\/em>.<\/p>\n\n\n\n<p>National Library of Medicine (2024) \u2018<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK598030\/\">Health Effects: Toxicological Profile for Propylene Glycol<\/a>*.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Key Takeaways Factory Origins Food vs Factory Synthetic B vitamins do not come from liver, eggs, beef, milk, or shellfish. They are made in factories. The process can use fermentation tanks, chemical reactions, purification steps, drying, and stabilizing. That alone makes them different from B vitamins found in food. Vitamin B12 is often made by &#8230; <a title=\"Synthetic B Vitamins Vs Natural &amp; Health Risks\" class=\"read-more\" href=\"https:\/\/openintegrative.com\/blog\/synthetic-b-vitamins-vs-natural-risks\/\" aria-label=\"Read more about Synthetic B Vitamins Vs Natural &amp; Health Risks\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":2748,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_wpscppro_dont_share_socialmedia":false,"_wpscppro_custom_social_share_image":0,"_facebook_share_type":"default","_twitter_share_type":"default","_linkedin_share_type":"default","_pinterest_share_type":"default","_linkedin_share_type_page":"default","_instagram_share_type":"default","_medium_share_type":"default","_threads_share_type":"default","_google_business_share_type":"default","_selected_social_profile":[],"_wpsp_enable_custom_social_template":false,"_wpsp_social_scheduling":{"enabled":true,"datetime":"2026-04-22 14:23:00","platforms":[],"status":"pending_publication","dateOption":"today","timeOption":"now","customDays":"","customHours":"","customDate":"","customTime":"","schedulingType":"absolute"},"_wpsp_active_default_template":true},"categories":[186,27],"tags":[398,399],"class_list":["post-2551","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-supplements-nutrients","category-vitamins","tag-b-vitamins","tag-folate"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Synthetic B Vitamins Vs Natural &amp; 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