{"id":3657,"date":"2026-09-05T06:38:00","date_gmt":"2026-09-05T10:38:00","guid":{"rendered":"https:\/\/openintegrative.com\/blog\/?p=3657"},"modified":"2026-07-12T11:46:31","modified_gmt":"2026-07-12T15:46:31","slug":"urolithin-a-energy-aging","status":"publish","type":"post","link":"https:\/\/openintegrative.com\/blog\/urolithin-a-energy-aging\/","title":{"rendered":"Can Urolithin A Boost Energy As You Age?"},"content":{"rendered":"\n<h2 id=\"h-key-takeaways\" class=\"wp-block-heading\"><strong>Key Takeaways<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Urolithin A may help older muscle clear damaged mitochondria and handle repeated work.<\/li>\n\n\n\n<li>Human trials show better muscle endurance, strength markers and some mitochondrial blood markers.<\/li>\n\n\n\n<li>Food sources depend on gut bacteria, so the same foods can give different results.<\/li>\n\n\n\n<li>Urolithin A works slowly through cell cleanup rather than a fast stimulant effect.<\/li>\n\n\n\n<li>Strength training, protein, sleep and minerals still carry the larger energy load.<\/li>\n<\/ul>\n\n\n\n<h2 id=\"h-urolithin-a-basics\" class=\"wp-block-heading\"><strong>Urolithin A Basics<\/strong><\/h2>\n\n\n\n<h3 id=\"h-cell-cleanup\" class=\"wp-block-heading\">Cell Cleanup<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Your muscles often tire faster as you get older. Damaged mitochondria can build up inside muscle cells and make energy production less steady. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Urolithin A helps trigger mitophagy, which is the cleanup process cells use to remove worn mitochondria. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Human research now links this compound to better muscle endurance and better mitochondrial markers in some groups (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39002645\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">1<\/a>).<\/p>\n\n\n\n<h3 id=\"h-muscle-energy\" class=\"wp-block-heading\">Muscle Energy<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Muscle energy depends on clean mitochondria and enough food coming in. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Weak mitochondria can make repeated work feel harder than it should. Better cleanup can help muscle keep going longer before fatigue takes over.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Urolithin A works slowly through cell repair signals. It does not push the nervous system like caffeine. People who expect a quick rush will judge it the wrong way. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The better test is repeated muscle work over several weeks, such as grip work, hill walking or lifting volume.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Older muscle also needs a strong signal from daily life. Lifting, carrying and sprinting tell the body to keep muscle tissue strong. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Enough complete protein gives the body material for repair. Sleep gives muscle time to recover from the work.<\/p>\n\n\n\n<h3 id=\"h-gut-bacteria\" class=\"wp-block-heading\">Gut Bacteria<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Your body can make urolithin A from compounds found in pomegranate, raspberries and walnuts. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Gut bacteria must turn those starting compounds into the final compound. Many people make little or none from the same foods, even when intake looks similar (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24976365\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">2<\/a>).<\/p>\n\n\n\n<h2 id=\"h-human-trial-results\" class=\"wp-block-heading\"><strong>Human Trial Results<\/strong><\/h2>\n\n\n\n<h3 id=\"h-older-adults\" class=\"wp-block-heading\">Older Adults<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">A trial in adults aged 65 to 90 used 1000 milligrams daily for four months. People taking urolithin A improved endurance in hand and leg muscle tests. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Their blood markers also moved in a direction linked with better mitochondrial health. The same study did not show a clear gain in six minute walk distance (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35050355\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">3<\/a>).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The result points to fatigue resistance during muscle work. It does not prove a broad rise in daily energy for everyone. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Some people may notice stairs feel easier or repeated tasks feel less draining. Others may notice little if sleep, food or training are poor.<\/p>\n\n\n\n<h3 id=\"h-middle-age\" class=\"wp-block-heading\">Middle Age<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">A trial in middle aged adults used 500 milligrams and 1000 milligrams daily for four months. People taking urolithin A improved some strength and exercise results. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Blood markers also pointed toward better mitochondrial function. The higher dose gave stronger signals in several measures (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35584623\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">4<\/a>).<\/p>\n\n\n\n<h3 id=\"h-trained-men\" class=\"wp-block-heading\">Trained Men<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">A trial in resistance trained men used 1000 milligrams daily for eight weeks. The men improved some strength and endurance measures. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Researchers also reported lower oxidative stress and lower inflammatory markers after training. This adds evidence in people who already ask their muscles to work hard (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39487653\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">5<\/a>).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Training gives a cleaner way to judge results. A person can track reps, load, walking distance or recovery between sessions. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Mood based energy is much harder to measure. A clear training log shows whether muscle is handling repeated work better.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">People who barely use their muscles may notice less. The body keeps tissue that receives a strong reason to stay. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Urolithin A may help cell cleanup, but muscle still needs work to stay strong. The strongest plan uses the compound around real training.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A person should also fix the obvious drains first. Poor sleep can erase any small gain from a supplement. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Low protein can slow repair. Too much sugar or starch can make energy swing up and down through the day.<\/p>\n\n\n\n<h2 id=\"h-food-training-amp-daily-base\" class=\"wp-block-heading\"><strong>Food, Training &amp; Daily Base<\/strong><\/h2>\n\n\n\n<h3 id=\"h-food-conversion\" class=\"wp-block-heading\">Food Conversion<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Pomegranate gives starting compounds, not a guaranteed dose of the final compound. Gut bacteria still have to convert them. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Many people do not convert them well. A food source can help some people, but it will not act the same in every gut.<\/p>\n\n\n\n<h3 id=\"h-better-muscle-base\" class=\"wp-block-heading\">Better Muscle Base<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Muscle needs real nutrition before a supplement can do much. Grass fed ruminant meat, organs and pasture raised eggs give complete protein and useful minerals. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Wild seafood can also work well. These foods give muscle the material it needs for repair.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Stable animal fats help keep food intake steady. Butter, ghee and tallow are better choices than seed oils. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Low fat eating can leave people underfed and weaker over time. Muscle repair needs enough protein, fat and minerals each day.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Carbohydrates should stay low enough to avoid energy swings. Frequent sugar and starch can make energy feel unstable. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Fortified grains are a poor base because they bring processed starch and added synthetic iron. Better meals rely on real food and no constant snacking.<\/p>\n\n\n\n<h3 id=\"h-strength-signal\" class=\"wp-block-heading\">Strength Signal<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Muscle stays stronger when it gets a clear demand. Lifting, carrying and sprinting tell the body to keep useful tissue. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The compound can help cleanup inside cells, but the muscle still needs a reason to stay strong. Training gives that reason.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">People who barely use their muscles may notice less. A cleanup signal works better when muscle is being used often. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Strength work gives the body a clear target for repair. Protein and sleep then help finish the job.<\/p>\n\n\n\n<h2 id=\"h-safety-amp-real-results\" class=\"wp-block-heading\"><strong>Safety &amp; Real Results<\/strong><\/h2>\n\n\n\n<h3 id=\"h-safety-record\" class=\"wp-block-heading\">Safety Record<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Human studies have reported good tolerance so far. Older adults, middle aged adults and trained men have used the compound in trials without major safety signals. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Most trials lasted weeks or months rather than years, so long term use still needs more human data (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35050355\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">3<\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32694802\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">6<\/a>).<\/p>\n\n\n\n<h3 id=\"h-daily-energy\" class=\"wp-block-heading\">Daily Energy<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Expect muscle changes before a clear change in daily energy. Better endurance during repeated work is the strongest human signal. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Stairs may feel easier. Training recovery may improve. A person may still feel no major <a href=\"https:\/\/openintegrative.com\/blog\/dna-longevity-can-you-live-to-200\/\">change<\/a> if sleep, food or movement are poor.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A 2024 review found five human studies with 250 healthy people. The review found anti inflammatory effects and changes in mitochondrial gene markers. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">It did not find clear gains in broad physical function or maximal ATP production. The human evidence is promising, but it is still limited (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39002645\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">1<\/a>).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A 2025 trial in healthy middle aged adults used 1000 milligrams daily for four weeks. Researchers reported changes in immune cell metabolism and markers linked with immune aging. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Immune cells also depend on mitochondria, so the result fits the wider cell cleanup picture (<a href=\"https:\/\/www.nature.com\/articles\/s43587-025-00996-x?\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">7<\/a>).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Four weeks only gives a short view. Healthy middle aged adults are also different from frail older adults. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The finding adds another human clue, but it does not prove broad anti aging effects. The most useful target remains muscle endurance and measurable recovery.<\/p>\n\n\n\n<h3 id=\"h-progress-tracking\" class=\"wp-block-heading\">Progress Tracking<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Pick one measure before starting. Use grip time, walking distance, stairs, lifting volume or recovery between hard sets. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Repeat the same test after eight to sixteen weeks. A clear measure keeps the result honest and reduces guessing from mood.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>For any health concerns or questions about a medical condition, get guidance from a physician or another appropriately trained clinician. Before changing your diet, supplements or health routine, talk with a licensed healthcare professional.<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n<style id=\"oi-smart-suggested-posts-css\">\n            .oi-sp,\n            .oi-sp *,\n            .oi-sp *::before,\n            .oi-sp *::after {\n                box-sizing: border-box !important;\n            }\n\n            .oi-sp {\n                display: block !important;\n                width: 100% !important;\n                max-width: 100% !important;\n                margin: 2rem 0 !important;\n                padding: 0 !important;\n                clear: both !important;\n                font-family: inherit !important;\n                color: #111 !important;\n            }\n\n            .oi-sp-heading {\n                display: block !important;\n                width: 100% !important;\n                margin: 0 0 1rem 0 !important;\n                padding: 0 !important;\n                color: #111 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}\n\n            @media (max-width: 900px) {\n                .oi-sp-smart .oi-sp-grid,\n                .oi-sp-similar .oi-sp-grid,\n                .oi-sp-related .oi-sp-grid,\n                .oi-sp-cornerstone .oi-sp-grid,\n                .oi-sp-pillar .oi-sp-grid,\n                .oi-sp-hub .oi-sp-grid,\n                .oi-sp-recent .oi-sp-grid,\n                .oi-sp-trending .oi-sp-grid {\n                    grid-template-columns: repeat(2, minmax(0, 1fr)) !important;\n                }\n\n                .oi-sp-top .oi-sp-grid {\n                    display: flex !important;\n                    flex-direction: column !important;\n                }\n            }\n\n            @media (max-width: 640px) {\n                .oi-sp-smart .oi-sp-grid,\n                .oi-sp-similar .oi-sp-grid,\n                .oi-sp-related .oi-sp-grid,\n                .oi-sp-cornerstone .oi-sp-grid,\n                .oi-sp-pillar .oi-sp-grid,\n                .oi-sp-hub .oi-sp-grid,\n                .oi-sp-recent .oi-sp-grid,\n                .oi-sp-trending .oi-sp-grid {\n                    grid-template-columns: 1fr !important;\n                }\n\n                .oi-sp-top .oi-sp-grid {\n                    display: flex !important;\n                    flex-direction: column !important;\n                }\n\n                .oi-sp-heading {\n                    font-size: 1.2rem !important;\n                }\n            }\n        <\/style><section class=\"oi-sp oi-sp-smart\" data-oi-sp-mode=\"smart\" aria-label=\"Suggested Posts\"><h2 class=\"oi-sp-heading\">Suggested Posts<\/h2><div class=\"oi-sp-grid\"><a class=\"oi-sp-card oi-sp-card-smart\" href=\"https:\/\/openintegrative.com\/blog\/____mitophagy-removes-damaged-mitochondria\/\"><div class=\"oi-sp-thumb\"><img decoding=\"async\" width=\"600\" height=\"600\" data-src=\"https:\/\/openintegrative.com\/blog\/wp-content\/uploads\/2026\/07\/Mitochondria-mitophagy.webp\" class=\"attachment-medium_large size-medium_large wp-post-image lazyload\" alt=\"\" data-srcset=\"https:\/\/openintegrative.com\/blog\/wp-content\/uploads\/2026\/07\/Mitochondria-mitophagy.webp 600w, https:\/\/openintegrative.com\/blog\/wp-content\/uploads\/2026\/07\/Mitochondria-mitophagy-300x300.webp 300w, https:\/\/openintegrative.com\/blog\/wp-content\/uploads\/2026\/07\/Mitochondria-mitophagy-150x150.webp 150w\" data-sizes=\"auto, (max-width: 600px) 100vw, 600px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 600px; --smush-placeholder-aspect-ratio: 600\/600;\" \/><\/div><div class=\"oi-sp-body\"><div class=\"oi-sp-title\">How Mitophagy Removes Your Damaged Mitochondria<\/div><div class=\"oi-sp-excerpt\">Key Takeaways Mitophagy clears damaged mitochondria before they create more stress inside your cells. Poor mitophagy can leave...<\/div><div class=\"oi-sp-read\">Read More<\/div><\/div><\/a><a class=\"oi-sp-card oi-sp-card-smart\" href=\"https:\/\/openintegrative.com\/blog\/nmn-benefits-for-energy-aging\/\"><div class=\"oi-sp-thumb\"><img decoding=\"async\" width=\"600\" height=\"600\" data-src=\"https:\/\/openintegrative.com\/blog\/wp-content\/uploads\/2026\/05\/NMN-.webp\" class=\"attachment-medium_large size-medium_large wp-post-image lazyload\" alt=\"\" data-srcset=\"https:\/\/openintegrative.com\/blog\/wp-content\/uploads\/2026\/05\/NMN-.webp 600w, https:\/\/openintegrative.com\/blog\/wp-content\/uploads\/2026\/05\/NMN--300x300.webp 300w, https:\/\/openintegrative.com\/blog\/wp-content\/uploads\/2026\/05\/NMN--150x150.webp 150w\" data-sizes=\"auto, (max-width: 600px) 100vw, 600px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 600px; --smush-placeholder-aspect-ratio: 600\/600;\" \/><\/div><div class=\"oi-sp-body\"><div class=\"oi-sp-title\">NMN Benefits For Energy &amp; Aging<\/div><div class=\"oi-sp-excerpt\">Key Takeaways NMN helps the body make NAD plus, a core molecule for cell energy. Human studies show...<\/div><div class=\"oi-sp-read\">Read More<\/div><\/div><\/a><a class=\"oi-sp-card oi-sp-card-smart\" href=\"https:\/\/openintegrative.com\/blog\/mitochondria-usable-energy\/\"><div class=\"oi-sp-thumb\"><img decoding=\"async\" width=\"600\" height=\"600\" data-src=\"https:\/\/openintegrative.com\/blog\/wp-content\/uploads\/2026\/09\/energy.webp\" class=\"attachment-medium_large size-medium_large wp-post-image lazyload\" alt=\"\" data-srcset=\"https:\/\/openintegrative.com\/blog\/wp-content\/uploads\/2026\/09\/energy.webp 600w, https:\/\/openintegrative.com\/blog\/wp-content\/uploads\/2026\/09\/energy-300x300.webp 300w, https:\/\/openintegrative.com\/blog\/wp-content\/uploads\/2026\/09\/energy-150x150.webp 150w\" data-sizes=\"auto, (max-width: 600px) 100vw, 600px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 600px; --smush-placeholder-aspect-ratio: 600\/600;\" \/><\/div><div class=\"oi-sp-body\"><div class=\"oi-sp-title\">Mitochondria 101 How Your Cells Make Usable Energy<\/div><div class=\"oi-sp-excerpt\">Key Takeaways Mitochondria turn food energy into ATP, the main usable energy molecule in cells. Most ATP comes...<\/div><div class=\"oi-sp-read\">Read More<\/div><\/div><\/a><\/div><\/section>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 id=\"h-research\" class=\"wp-block-heading\"><strong>Research<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Kuerec, A.H. et al. 2024. Targeting aging with urolithin A in humans: A systematic review. Ageing Research Reviews. DOI: 10.1016\/j.arr.2024.102397. PMID: 39002645.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Tom\u00e1s-Barber\u00e1n, F.A. et al. 2014. Ellagic acid metabolism by human gut microbiota: Consistent observation of three urolithin phenotypes in intervention trials, independent of food source, age and health status. Journal of Agricultural and Food Chemistry. DOI: 10.1021\/jf5024615. PMID: 24976365.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Liu, S. et al. 2022. Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial. JAMA Network Open. DOI: 10.1001\/jamanetworkopen.2021.44279. PMID: 35050355.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Singh, A. et al. 2022. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell Reports Medicine. DOI: 10.1016\/j.xcrm.2022.100633. PMID: 35584623.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Zhao, H. et al. 2024. Assessment of Urolithin A effects on muscle endurance, strength, inflammation, oxidative stress and protein metabolism in male athletes with resistance training: an 8-week randomized, double-blind, placebo-controlled study. Journal of the International Society of Sports Nutrition. DOI: 10.1080\/15502783.2024.2419388. PMID: 39487653.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Andreux, P.A. et al. 2019. The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. Nature Metabolism. DOI: 10.1038\/s42255-019-0073-4. PMID: 32694802.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Denk, D. et al. 2025. Effect of the mitophagy inducer urolithin A on age-related immune remodeling in humans. Nature Aging. DOI: 10.1038\/s43587-025-00996-x.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Faitg, J. et al. 2023. Mitophagy activation by urolithin A to target muscle aging. International Journal of Molecular Sciences. DOI: 10.3390\/ijms25010001.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Zhao, H. et al. 2023. Pharmacological effects of urolithin A and its role in muscle health and performance. Nutrients. DOI: 10.3390\/nu15224757.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">D\u2019Amico, D. et al. 2021. Urolithin A improves mitochondrial health, reduces cartilage degeneration and alleviates pain in osteoarthritis. Aging Cell. DOI: 10.1111\/acel.13494.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Gonz\u00e1lez-Sarr\u00edas, A. et al. 2017. Urolithins, the rescue of old metabolites to understand a new concept: Metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis and host health status. Molecular Nutrition &amp; Food Research. DOI: 10.1002\/mnfr.201500901.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Kujawska, M. and Jodynis-Liebert, J. 2020. Potential of the ellagic acid derived gut microbiota metabolite urolithin A in gastrointestinal protection. World Journal of Gastroenterology. DOI: 10.3748\/wjg.v26.i23.3170.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Banc, R. et al. 2023. The impact of ellagitannins and their metabolites through gut microbiome on gut health and brain wellness within the gut brain axis. Foods. DOI: 10.3390\/foods12020270.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Liu, H. et al. 2024. Correlation between intestinal microbiota and urolithin production after ellagic acid intake. Food &amp; Function. DOI: 10.1039\/d4fo01821a.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Pidgeon, R. et al. 2025. Diet derived urolithin A is produced by a dehydroxylase encoded by the human gut microbiome. Nature Communications. DOI: 10.1038\/s41467-025-56266-2.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Key Takeaways Urolithin A Basics Cell Cleanup Your muscles often tire faster as you get older. Damaged mitochondria can build up inside muscle cells and make energy production less steady. Urolithin A helps trigger mitophagy, which is the cleanup process cells use to remove worn mitochondria. Human research now links this compound to better muscle &#8230; <a title=\"Can Urolithin A Boost Energy As You Age?\" class=\"read-more\" href=\"https:\/\/openintegrative.com\/blog\/urolithin-a-energy-aging\/\" aria-label=\"Read more about Can Urolithin A Boost Energy As You Age?\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":5324,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_wpscppro_dont_share_socialmedia":false,"_wpscppro_custom_social_share_image":0,"_facebook_share_type":"default","_twitter_share_type":"default","_linkedin_share_type":"default","_pinterest_share_type":"default","_linkedin_share_type_page":"default","_instagram_share_type":"default","_medium_share_type":"default","_threads_share_type":"default","_google_business_share_type":"default","_bluesky_share_type":"","_mastodon_share_type":"","_selected_social_profile":[],"_wpsp_enable_custom_social_template":false,"_wpsp_social_scheduling":{"enabled":false,"datetime":null,"platforms":[],"status":"template_only","dateOption":"today","timeOption":"in_1h","customDays":"","customHours":"","customDate":"","customTime":"","schedulingType":"absolute"},"_wpsp_active_default_template":true},"categories":[180,181],"tags":[453,378,572],"class_list":["post-3657","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-longevity-cellular-health","category-mitochondrial-health","tag-healthy-aging","tag-mitophagy","tag-urolithin-a","no-featured-image-padding"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.4 (Yoast SEO v28.5) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Can Urolithin A Boost Energy As You Age? 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