{"id":540,"date":"2026-04-10T01:21:00","date_gmt":"2026-04-10T05:21:00","guid":{"rendered":"https:\/\/openintegrative.com\/blog\/?p=540"},"modified":"2026-06-14T17:52:37","modified_gmt":"2026-06-14T21:52:37","slug":"proteolytic-enzymes-heart-health","status":"publish","type":"post","link":"https:\/\/openintegrative.com\/blog\/proteolytic-enzymes-heart-health\/","title":{"rendered":"Proteolytic Enzymes &amp; Heart Health: What the Research Shows"},"content":{"rendered":"\n<h2 id=\"h-key-takeaways\" class=\"wp-block-heading\"><strong>Key Takeaways<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>These enzymes help break down fibrin, a protein in blood clots<\/li>\n\n\n\n<li>Nattokinase has the best human heart-health research of the four<\/li>\n\n\n\n<li>Serrapeptase and bromelain are studied more for swelling and inflammation<\/li>\n\n\n\n<li>Lumbrokinase is a strong fibrin-clearing enzyme from earthworms<\/li>\n\n\n\n<li>Food quality and meal rhythm still matter most for vascular health<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Blood needs to flow with ease. The body makes clots to stop bleeding, then clears them when the job is done. This clean up step helps keep blood moving through small and large vessels. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A group of enzymes may help with that process. These include <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>nattokinase, <\/li>\n\n\n\n<li>serrapeptase, <\/li>\n\n\n\n<li>lumbrokinase, and <\/li>\n\n\n\n<li>bromelain. <\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Each one works in a different way, and each has a different level of research behind it.<\/p>\n\n\n\n<h2 id=\"h-nattokinase\" class=\"wp-block-heading\"><strong>Nattokinase<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\" id=\"h-what-it-is\">Nattokinase is an enzyme found in natto, a fermented soybean food from Japan. It is made during fermentation by <em>Bacillus subtilis<\/em>. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\" id=\"h-what-it-is\">Scientists first drew notice to nattokinase after finding that it could break down fibrin, the net-like protein that helps form a clot (<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6043915\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Chen et al., 2018<\/a>). <\/p>\n\n\n\n<p class=\"wp-block-paragraph\" id=\"h-what-it-is\">Fibrin is useful when the body needs to seal a wound. Trouble can start when too much fibrin stays in place. That can make blood thicker and flow less well.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Natural fibrinolytic enzymes are also found in some other fermented foods. A recent review of food-based enzymes notes that these compounds are of interest because they can help break down fibrin and support the body\u2019s own clot-control system (<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10563737\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Wang et al., 2023<\/a>).<\/p>\n\n\n\n<h3 id=\"h-benefits-of-nattokinase\" class=\"wp-block-heading\">Benefits of Nattokinase<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Of the enzymes in this article, nattokinase has the strongest human research for heart and vessel health. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A meta-analysis published in 2024 found that nattokinase supplementation lowered systolic and diastolic blood pressure in the trials it reviewed (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39076715\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Li et al., 2024<\/a>). <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Nattokinase has enough human data to stand out from the rest of this group.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Researchers also study nattokinase for its effect on fibrin, blood flow, and other markers tied to vascular health. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Reviews describe it as a promising enzyme for circulation support, while also noting that more strong trials are still needed (<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6043915\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Chen et al., 2018<\/a>).<\/p>\n\n\n\n<h2 id=\"h-serrapeptase\" class=\"wp-block-heading\"><strong>Serrapeptase<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\" id=\"h-what-it-is-0\">Serrapeptase, also called serratiopeptidase, is a proteolytic enzyme. That means it breaks proteins into smaller parts. It was first linked with bacteria found in the gut of the silkworm.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This enzyme is not mainly known for direct heart effects. It is better known for work on swelling, mucus, and tissue debris. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Reviews describe it as an anti-inflammatory enzyme, but also note that the clinical evidence is mixed and not very strong in many areas (<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7032259\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Tiwari, 2017<\/a>).<\/p>\n\n\n\n<h3 id=\"h-benefits-of-serrapeptase\" class=\"wp-block-heading\">Benefits of Serrapeptase<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Serrapeptase gets attention because chronic inflammation can harm blood vessels over time. If an enzyme helps clear inflammatory debris, that may support better tissue function.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Still, this point needs care. The best review data says the evidence for serrapeptase is limited, and long-term safety data are also limited (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23380245\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Bhagat et al., 2013<\/a>).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">So its value in cardiovascular health is more indirect than direct. It may help by lowering swelling and protein waste in tissues, but it does not have the same level of heart specific human evidence as nattokinase.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Serrapeptase may fit a broad plan aimed at reducing inflammation, but it should not be framed as a proven heart health tool.<\/p>\n\n\n\n<h2 id=\"h-lumbrokinase\" class=\"wp-block-heading\"><strong>Lumbrokinase<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\" id=\"h-what-it-is-1\">Lumbrokinase is a group of enzymes taken from earthworms. It is known for strong fibrin-breaking action. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\" id=\"h-what-it-is-1\">Reviews of natural fibrinolytic enzymes list lumbrokinase as one of the more active agents in this field (<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10907686\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Hazare et al., 2024<\/a>). <\/p>\n\n\n\n<p class=\"wp-block-paragraph\" id=\"h-what-it-is-1\">Older lab work found that earthworm-derived enzymes can dissolve fibrin well, which is why lumbrokinase drew interest in the first place (<a href=\"https:\/\/europepmc.org\/article\/med\/1960890\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Mihara et al., 1991<\/a>).<\/p>\n\n\n\n<h3 id=\"h-benefits-of-lumbrokinase\" class=\"wp-block-heading\">Benefits of Lumbrokinase<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Lumbrokinase is often described as more fibrin-specific than many other enzymes. In plain words, that means it may focus more on fibrin and less on other proteins. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Reviews discuss its use in thrombosis and circulation research, but most of the stronger claims still need better human trials in broader groups (<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10907686\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Hazare et al., 2024<\/a>). <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Lumbrokinase is a potent enzyme with a strong theory behind it. The clinical proof is still thinner than many supplement ads suggest.<\/p>\n\n\n\n<h2 id=\"h-bromelain\" class=\"wp-block-heading\"><strong>Bromelain<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\" id=\"h-what-it-is-2\">Bromelain is a mix of enzymes from pineapple, most of all the stem. It is a proteolytic enzyme, so it helps break down proteins. It has been studied for swelling, pain, tissue healing, and immune effects.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Modern reviews describe bromelain as anti-inflammatory, anti-edema, and antithrombotic in a range of lab and animal work (<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8534447\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Varilla et al., 2021<\/a>).<\/p>\n\n\n\n<h3 id=\"h-benefits-of-bromelain\" class=\"wp-block-heading\">Benefits of Bromelain<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Bromelain is often grouped with circulatory enzymes because inflammation and clotting affect each other. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A vessel under stress tends to become more sticky and inflamed. An enzyme that helps calm swelling may support better flow.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">At the same time, most of the strongest bromelain evidence is still for inflammation and swelling rather than direct heart endpoints. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A recent review also notes these anti-inflammatory effects, while calling for more high-quality human trials (<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11243481\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Kansakar et al., 2024<\/a>).<\/p>\n\n\n\n<h2 id=\"h-enzymes-amp-drug-care\" class=\"wp-block-heading\"><strong>Enzymes &amp; Drug Care<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\" id=\"h-how-they-differ\">These enzymes are not the same as clot busting drugs or prescription blood thinners. Drugs act in a stronger and more direct way. In emergency care, that can save life and tissue.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Natural enzymes work in a softer way. They support the body\u2019s own systems for clearing fibrin and protein debris. <\/p>\n\n\n\n<h3 id=\"h-food\" class=\"wp-block-heading\">Food<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The body builds enzymes from amino acids and minerals. Nutrient dense meals support that work. One to three meals per day may also help reduce constant blood sugar swings and snacking stress.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Enzyme support works best when the rest of the diet is solid. That means enough protein, enough animal fat, fewer ultra-processed foods, and less seed oil. Fermented foods may also add useful compounds, though not every enzyme can be gained in a food amount.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Consult a licensed healthcare professional before starting, stopping, or changing any diet, supplement, medication, or wellness practice. For questions about a medical condition or symptoms, seek advice from a qualified clinician who can assess your situation.<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n<style id=\"oi-smart-suggested-posts-css\">\n            .oi-sp,\n            .oi-sp *,\n            .oi-sp *::before,\n            .oi-sp *::after {\n                box-sizing: border-box !important;\n            }\n\n            .oi-sp {\n                display: block !important;\n                width: 100% !important;\n                max-width: 100% !important;\n                margin: 2rem 0 !important;\n                padding: 0 !important;\n                clear: both !important;\n                font-family: inherit !important;\n                color: #111 !important;\n            }\n\n            .oi-sp-heading {\n                display: block !important;\n                width: 100% !important;\n                margin: 0 0 1rem 0 !important;\n    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flex-direction: column !important;\n                align-items: stretch !important;\n                justify-content: flex-start !important;\n                width: 100% !important;\n                gap: 0 !important;\n                margin: 0 !important;\n                padding: 0 !important;\n            }\n\n            .oi-sp-top .oi-sp-card {\n                display: flex !important;\n                flex-direction: column !important;\n                width: 100% !important;\n                max-width: 100% !important;\n                margin: 0 0 1.15rem 0 !important;\n                border-radius: 12px !important;\n            }\n\n            .oi-sp-top .oi-sp-card:last-child {\n                margin-bottom: 0 !important;\n            }\n\n            .oi-sp-top .oi-sp-thumb {\n                aspect-ratio: 16 \/ 9 !important;\n            }\n\n            .oi-sp-top .oi-sp-body {\n                display: flex !important;\n                flex-direction: column 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!important;\n                font-weight: 800 !important;\n            }\n\n            @media (max-width: 900px) {\n                .oi-sp-smart .oi-sp-grid,\n                .oi-sp-similar .oi-sp-grid,\n                .oi-sp-related .oi-sp-grid,\n                .oi-sp-cornerstone .oi-sp-grid,\n                .oi-sp-pillar .oi-sp-grid,\n                .oi-sp-hub .oi-sp-grid,\n                .oi-sp-recent .oi-sp-grid,\n                .oi-sp-trending .oi-sp-grid {\n                    grid-template-columns: repeat(2, minmax(0, 1fr)) !important;\n                }\n\n                .oi-sp-top .oi-sp-grid {\n                    display: flex !important;\n                    flex-direction: column !important;\n                }\n            }\n\n            @media (max-width: 640px) {\n                .oi-sp-smart .oi-sp-grid,\n                .oi-sp-similar .oi-sp-grid,\n                .oi-sp-related .oi-sp-grid,\n                .oi-sp-cornerstone .oi-sp-grid,\n                .oi-sp-pillar .oi-sp-grid,\n                .oi-sp-hub .oi-sp-grid,\n                .oi-sp-recent .oi-sp-grid,\n                .oi-sp-trending .oi-sp-grid {\n                    grid-template-columns: 1fr !important;\n                }\n\n                .oi-sp-top .oi-sp-grid {\n                    display: flex !important;\n                    flex-direction: column !important;\n                }\n\n                .oi-sp-heading {\n                    font-size: 1.2rem !important;\n                }\n            }\n        <\/style><section class=\"oi-sp oi-sp-smart\" data-oi-sp-mode=\"smart\" aria-label=\"Suggested Posts\"><h2 class=\"oi-sp-heading\">Suggested Posts<\/h2><div class=\"oi-sp-grid\"><a class=\"oi-sp-card oi-sp-card-smart\" href=\"https:\/\/openintegrative.com\/blog\/c-reactive-protein-crp\/\"><div class=\"oi-sp-thumb\"><img decoding=\"async\" width=\"600\" height=\"600\" data-src=\"https:\/\/openintegrative.com\/blog\/wp-content\/uploads\/2026\/04\/crp.webp\" 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href=\"https:\/\/openintegrative.com\/blog\/high-homocysteine-how-to-manage-levels\/\"><div class=\"oi-sp-thumb\"><img decoding=\"async\" width=\"600\" height=\"600\" data-src=\"https:\/\/openintegrative.com\/blog\/wp-content\/uploads\/2026\/03\/Homocysteine-96.webp\" class=\"attachment-medium_large size-medium_large wp-post-image lazyload\" alt=\"homocysteine\" data-srcset=\"https:\/\/openintegrative.com\/blog\/wp-content\/uploads\/2026\/03\/Homocysteine-96.webp 600w, https:\/\/openintegrative.com\/blog\/wp-content\/uploads\/2026\/03\/Homocysteine-96-300x300.webp 300w, https:\/\/openintegrative.com\/blog\/wp-content\/uploads\/2026\/03\/Homocysteine-96-150x150.webp 150w\" data-sizes=\"auto, (max-width: 600px) 100vw, 600px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 600px; --smush-placeholder-aspect-ratio: 600\/600;\" \/><\/div><div class=\"oi-sp-body\"><div class=\"oi-sp-title\">Homocysteine &amp; Human Health: What Research Reveals<\/div><div class=\"oi-sp-excerpt\">Key Takeaways Homocysteine is made in the body during normal protein use. High homocysteine is linked with more...<\/div><div class=\"oi-sp-read\">Read More<\/div><\/div><\/a><a class=\"oi-sp-card oi-sp-card-smart\" href=\"https:\/\/openintegrative.com\/blog\/coq10-what-it-is-why-it-matters\/\"><div class=\"oi-sp-thumb\"><img decoding=\"async\" width=\"600\" height=\"600\" data-src=\"https:\/\/openintegrative.com\/blog\/wp-content\/uploads\/2026\/04\/coq10-34.webp\" class=\"attachment-medium_large size-medium_large wp-post-image lazyload\" alt=\"COQ10\" data-srcset=\"https:\/\/openintegrative.com\/blog\/wp-content\/uploads\/2026\/04\/coq10-34.webp 600w, https:\/\/openintegrative.com\/blog\/wp-content\/uploads\/2026\/04\/coq10-34-300x300.webp 300w, https:\/\/openintegrative.com\/blog\/wp-content\/uploads\/2026\/04\/coq10-34-150x150.webp 150w\" data-sizes=\"auto, (max-width: 600px) 100vw, 600px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 600px; --smush-placeholder-aspect-ratio: 600\/600;\" \/><\/div><div class=\"oi-sp-body\"><div class=\"oi-sp-title\">CoQ10: What It Is &amp; Why It Matters<\/div><div class=\"oi-sp-excerpt\">Key Takeaways CoQ10 helps cells make energy for the heart, brain and muscles. The body makes CoQ10, but...<\/div><div class=\"oi-sp-read\">Read More<\/div><\/div><\/a><\/div><\/section>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 id=\"h-research\" class=\"wp-block-heading\"><strong>Research<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Chen, H. et al. (2018) \u2018Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases\u2019, <em>Biomarker Insights<\/em>. <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6043915\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Link<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Wang, P. et al. (2023) \u2018Research progress on the fibrinolytic enzymes produced from microorganisms and their applications\u2019, <em>Heliyon<\/em>. <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10563737\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Link<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Li, X. et al. (2024) \u2018Nattokinase Supplementation and Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials\u2019, <em>Nutrients<\/em>. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39076715\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Link<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Tiwari, M. (2017) \u2018The role of serratiopeptidase in the resolution of inflammation\u2019, <em>Asian Journal of Pharmaceutical Sciences<\/em>. <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7032259\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Link<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Hazare, C. et al. (2024) \u2018Diverse origins of fibrinolytic enzymes: A comprehensive review\u2019, <em>Heliyon<\/em>. <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10907686\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Link<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Mihara, H. et al. (1991) \u2018A novel fibrinolytic enzyme extracted from the earthworm, Lumbricus rubellus\u2019, <em>Japanese Journal of Physiology<\/em>. <a href=\"https:\/\/europepmc.org\/article\/med\/1960890\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Link<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Varilla, C. et al. (2021) \u2018Bromelain, a Group of Pineapple Proteolytic Complex Enzymes\u2019, <em>Current Pharmaceutical Design<\/em>. <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8534447\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Link<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Kansakar, U. et al. (2024) \u2018Exploring the Therapeutic Potential of Bromelain: Current Knowledge and Prospective Uses\u2019, <em>Biomedicines<\/em>. <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11243481\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Link<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Kasim, M., Kiat, A.A., Rohman, M.S., Hanifah, Y. &amp; Kiat, H. (2015) \u2018Lumbrokinase for prevention of ischemic stroke: A systematic review and meta-analysis\u2019, <em>Drug Design, Development and Therapy<\/em>. <a href=\"https:\/\/doi.org\/10.2147\/DDDT.S79585\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Link<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Jensen, G.S., Lenninger, M., Ero, M.P. &amp; Benson, K.F. (2016) \u2018Consumption of nattokinase is associated with reduced blood pressure and von Willebrand factor, a cardiovascular risk marker: Results from a randomized, double-blind, placebo-controlled multicenter North American clinical trial\u2019, <em>Scientific Reports<\/em>. <a href=\"https:\/\/doi.org\/10.1038\/srep28598\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Link<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Kim, J.Y., Gum, S.N., Paik, J.K., Lim, H.H., Kim, K.C., Ogasawara, K., Inoue, K., Park, S., Jang, Y. &amp; Lee, J.H. (2008) \u2018Effects of nattokinase on blood pressure: A randomized, controlled trial\u2019, <em>Hypertension Research<\/em>. <a href=\"https:\/\/doi.org\/10.1291\/hypres.31.1583\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Link<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Hsia, C.H., Shen, M.C., Lin, J.S., Wen, Y.K., Hwang, K.L., Cham, T.M. &amp; Yang, N.C. (2009) \u2018Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects\u2019, <em>Nutrition Research<\/em>. <a href=\"https:\/\/doi.org\/10.1016\/j.nutres.2009.07.018\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Link<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Kee, W.H., Tan, S.L., Lee, V. &amp; Salmon, Y.M. (1989) \u2018The treatment of breast engorgement with serrapeptase (Danzen): A randomized double-blind controlled trial\u2019, <em>Singapore Medical Journal<\/em>. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/2487301\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Link<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Mazzone, A., Catalani, M., Costanzo, M., Drusian, A., Mandoli, A., Russo, S., Guarini, E. &amp; Vesperini, G. (1990) \u2018Evaluation of serrapeptase in acute or chronic inflammation of otorhinolaryngology pathology: A multicentre, double-blind study versus placebo\u2019, <em>International Journal of Clinical Pharmacology, Therapy, and Toxicology<\/em>. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/2487899\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Link<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Sumi, H., Hamada, H., Tsushima, H., Mihara, H. &amp; Muraki, H. (1987) \u2018A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese natto; a typical and popular soybean food in the Japanese diet\u2019, <em>Experientia<\/em>. <a href=\"https:\/\/doi.org\/10.1007\/BF01956052\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Link<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Maurer, H.R. (2001) \u2018Bromelain: Biochemistry, pharmacology and medical use\u2019, <em>Cellular and Molecular Life Sciences<\/em>. <a href=\"https:\/\/doi.org\/10.1007\/PL00000936\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Link<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Pavan, R., Jain, S., Shraddha &amp; Kumar, A. (2012) \u2018Properties and therapeutic application of bromelain: A review\u2019, <em>Biotechnology Research International<\/em>. <a href=\"https:\/\/doi.org\/10.1155\/2012\/976203\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Link<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Taussig, S.J. &amp; Batkin, S. (1988) \u2018Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update\u2019, <em>Journal of Ethnopharmacology<\/em>. <a href=\"https:\/\/doi.org\/10.1016\/0378-8741(88)90127-4\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Link<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Bhagat, S., Agarwal, M. &amp; Roy, V. (2013) \u2018Serratiopeptidase: A systematic review of the existing evidence\u2019, <em>International Journal of Surgery<\/em>. <a href=\"https:\/\/doi.org\/10.1016\/j.ijsu.2013.05.014\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Link<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Mine, Y., Wong, A.H.K. &amp; Jiang, B. (2005) \u2018Fibrinolytic enzymes in Asian traditional fermented foods\u2019, <em>Food Research International<\/em>. <a href=\"https:\/\/doi.org\/10.1016\/j.foodres.2004.07.008\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Link<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Choi, N.S., Song, J.J., Chung, D.M., Kim, Y.J., Maeng, P.J. &amp; Kim, S.H. (2005) \u2018Purification and characterization of a novel fibrinolytic enzyme from Bacillus sp. isolated from fermented soybean food\u2019, <em>Journal of Biochemistry and Molecular Biology<\/em>. <a href=\"https:\/\/doi.org\/10.5483\/BMBRep.2005.38.4.512\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Link<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Uchida, S., Yamada, Y., Kato, H. &amp; Sumi, H. (2015) \u2018Nattokinase: A potent blood-clot dissolving enzyme with cardiovascular benefits\u2019, <em>International Journal of Molecular Sciences<\/em>. <a href=\"https:\/\/doi.org\/10.3390\/ijms16032780\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Link<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Secor, E.R. Jr., Carson, W.F., Singh, A., Pensa, M., Guernsey, L.A., Schramm, C.M. &amp; Thrall, R.S. (2005) \u2018Oral bromelain attenuates inflammation in an ovalbumin-induced murine model of asthma\u2019, <em>Cellular Immunology<\/em>. <a href=\"https:\/\/doi.org\/10.1016\/j.cellimm.2005.05.012\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Link<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Fitzhugh, D.J., Shan, S., Dewhirst, M.W. &amp; Hale, L.P. (2008) \u2018Bromelain treatment decreases neutrophil migration to sites of inflammation\u2019, <em>Clinical Immunology<\/em>. <a href=\"https:\/\/doi.org\/10.1016\/j.clim.2008.04.002\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Link<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Verma, S., Singh, A. &amp; Mishra, A. (2017) \u2018Serratiopeptidase: Insights into the therapeutic applications\u2019, <em>Biotechnology Reports<\/em>. <a href=\"https:\/\/doi.org\/10.1016\/j.btre.2017.01.001\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">Link<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Key Takeaways Blood needs to flow with ease. The body makes clots to stop bleeding, then clears them when the job is done. This clean up step helps keep blood moving through small and large vessels. A group of enzymes may help with that process. These include Each one works in a different way, and &#8230; <a title=\"Proteolytic Enzymes &amp; Heart Health: What the Research Shows\" class=\"read-more\" href=\"https:\/\/openintegrative.com\/blog\/proteolytic-enzymes-heart-health\/\" aria-label=\"Read more about Proteolytic Enzymes &amp; Heart Health: What the Research Shows\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":1669,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_wpscppro_dont_share_socialmedia":false,"_wpscppro_custom_social_share_image":0,"_facebook_share_type":"default","_twitter_share_type":"default","_linkedin_share_type":"default","_pinterest_share_type":"default","_linkedin_share_type_page":"default","_instagram_share_type":"default","_medium_share_type":"default","_threads_share_type":"default","_google_business_share_type":"default","_selected_social_profile":[],"_wpsp_enable_custom_social_template":false,"_wpsp_social_scheduling":{"enabled":true,"datetime":"2026-04-10 05:21:00","platforms":[],"status":"pending_publication","dateOption":"today","timeOption":"now","customDays":"","customHours":"","customDate":"","customTime":"","schedulingType":"absolute"},"_wpsp_active_default_template":true},"categories":[226,189,163],"tags":[324,290,313,686],"class_list":["post-540","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cardiovascular-health","category-specialized-supplements","category-vascular-function","tag-fibrin","tag-inflammation","tag-oxidative-stress","tag-proteolytic-enzymes","no-featured-image-padding"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.9 (Yoast SEO v27.9) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Proteolytic Enzymes &amp; 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