Key Takeaways
- Insulin resistance leads to high blood sugar when cells stop responding to insulin.
- Often connected to obesity, poor diet, and physical inactivity.
- Symptoms include weight gain, fatigue, and cravings for sugar.
- Management focuses on a low-carb, high-fat diet, regular exercise, and stress reduction.
- Early treatment helps prevent type 2 diabetes and heart issues.
What is Insulin Resistance?
Insulin’s Role in the Body
Insulin is released by the pancreas when glucose from food enters the bloodstream. Its job is to help glucose enter cells for energy.
Without proper insulin function, glucose remains in the blood, leading to high sugar levels.
How Insulin Resistance Develops
Over time, a poor diet high in processed foods, refined carbs, and unhealthy fats can overwhelm the body’s ability to regulate insulin.
Cells gradually become resistant, needing more insulin to process the same amount of glucose. This process raises blood sugar and insulin levels.
Symptoms and Diagnosis
Common Symptoms
Symptoms may include fatigue, constant hunger, weight gain, difficulty losing weight, and darkened patches of skin, especially around the neck and armpits.
Diagnostic Methods
Doctors diagnose insulin resistance through blood tests measuring fasting glucose, insulin levels, and HbA1c, a marker of long-term blood sugar levels.
An oral glucose tolerance test can also reveal how efficiently the body handles sugar.
Causes and Risk Factors
Obesity and Diet
Excess body fat, particularly around the abdomen, increases the risk of insulin resistance. Diets high in refined carbohydrates and sugar often trigger the condition.
Sedentary Lifestyle
Lack of physical activity worsens insulin sensitivity. Regular movement helps cells use glucose more effectively.
Genetic Predisposition
Some individuals may inherit a tendency to develop insulin resistance, especially if there is a family history of type 2 diabetes.
Stress and Inflammation
Chronic stress increases cortisol, a hormone that can worsen insulin resistance. Inflammation in the body also plays a role in reducing insulin sensitivity.
Complications of Insulin Resistance
Link to Type 2 Diabetes
Without intervention, insulin resistance can develop into type 2 diabetes. In this stage, the pancreas struggles to keep up with insulin demand, causing blood sugar to rise dangerously high.
Cardiovascular Issues
Insulin resistance is strongly connected to heart disease. High insulin levels contribute to increased blood pressure and cholesterol, which raise the risk of heart attack and stroke.
Fatty Liver Disease
Excess insulin can cause the liver to store more fat, leading to non-alcoholic fatty liver disease (NAFLD), a condition that affects liver function.
Managing Insulin Resistance
Dietary Adjustments
A low-carb, high-fat diet is recommended to manage insulin resistance. Focus on animal-based foods such as grass-fed red meat, eggs, butter, ghee, and wild-caught seafood.
Make an effort to maximize you bioavailable copper levels. These foods help stabilize blood sugar and improve insulin sensitivity.
Avoid high-carb and high-sugar foods like grains, sugary snacks, and starchy vegetables. Stay away from fructose and anything fortified especially with iron and iron-containing supplements.
Physical Activity and Exercise
Regular exercise, especially strength training and aerobic activities, helps the body use insulin more efficiently. Exercise increases glucose uptake by cells, reducing insulin levels.
Stress Management
Reducing stress through practices like meditation, deep breathing, or yoga helps lower cortisol levels. This reduces the negative impact of stress on insulin sensitivity.
The Role of Sleep
Good sleep is essential for managing insulin resistance. Poor sleep increases insulin resistance, while quality sleep supports hormone balance and blood sugar regulation.
Medical Options
Medications for Insulin Resistance
Doctors may prescribe medications like metformin to help control blood sugar levels and improve insulin sensitivity. However, lifestyle changes remain the most effective management strategy.
Regular Monitoring of Blood Sugar
Monitoring blood sugar levels helps track progress and adjust diet and lifestyle as needed. Devices such as glucose monitors can be used to maintain optimal levels.
Working with Healthcare Providers
Working closely with healthcare professionals ensures proper diagnosis, management, and prevention of further complications.
Prevention and Long-Term Management
Lifestyle Changes for Long-Term Control
Adopting a sustainable, nutrient-dense diet and engaging in regular exercise can control insulin resistance. Consistency in lifestyle changes is key to preventing its progression.
Regular Check-ups
Frequent check-ups and blood sugar monitoring allow early detection of any worsening symptoms. Preventative care helps manage the condition effectively.
Preventing the Onset of Type 2 Diabetes
With proper management, insulin resistance can be reversed, reducing the risk of developing type 2 diabetes. Early interventions make a significant difference in long-term health outcomes.
FAQs
Can insulin resistance be reversed?
Yes, with dietary changes, exercise, and stress reduction, insulin resistance can be improved or reversed.
How does insulin resistance affect weight loss?
Insulin resistance makes it difficult to lose weight because high insulin levels promote fat storage.
What foods should be avoided with insulin resistance?
Avoid high-carb, high-sugar foods like grains, sugary snacks, and starchy vegetables.
Are there supplements that help with insulin resistance?
Focus on animal-based nutrient-dense foods instead of supplements, as they provide the best bioavailable nutrients.
How does stress impact insulin resistance?
Chronic stress raises cortisol levels, which can worsen insulin resistance and increase blood sugar levels.
Research
Arumugam, S. and Suyambulingam, A., 2024. Association Between Serum Ferritin and the Duration of Type 2 Diabetes Mellitus in a Tertiary Care Hospital in Chennai. Cureus. [online] https://doi.org/10.7759/cureus.53117.
Chitturi, S. and George, J., 2003. Interaction of iron, insulin resistance, and nonalcoholic steatohepatitis. Curr Gastroenterol Rep, [online] 5(1), pp.18-25. https://doi.org/10.1007/s11894-003-0005-y.
DiNicolantonio, J.J., Mangan, D. and O’Keefe, J.H., 2018. Copper deficiency may be a leading cause of ischaemic heart disease. Open Heart, [online] 5(2), p.e000784. https://doi.org/10.1136/openhrt-2018-000784.
DiNicolantonio, J.J., Mangan, D. and O’Keefe, J.H., 2018. The fructose–copper connection: Added sugars induce fatty liver and insulin resistance via copper deficiency. Journal of Metabolic Health, [online] 3(1). https://doi.org/10.4102/jir.v3i1.43.
Dubey, P., Thakur, V. and Chattopadhyay, M., 2020. Role of Minerals and Trace Elements in Diabetes and Insulin Resistance. Nutrients, [online] 12(6), p.1864. https://doi.org/10.3390/nu12061864.
Ferrannini, E., Vichi, S., Beck-Nielsen, H., Laakso, M., Paolisso, L. and Smith, G., 1996. Insulin Action and Age: European Group for the Study of Insulin Resistance (EGIR). Diabetes, [online] 45(7), pp.947–953. https://doi.org/10.2337/diab.45.7.947.
Freeman, A.M., Acevedo, L.A. and Pennings, N., 2023. Insulin Resistance. In: StatPearls. StatPearls Publishing, Treasure Island (FL). PMID: 29939616.
Jiang, X., Hu, R., Huang, Y., Xu, Y., Zheng, Z., Shi, Y., Miao, J. and Liu, Y., 2023. Fructose aggravates copper-deficiency-induced non-alcoholic fatty liver disease. The Journal of Nutritional Biochemistry, [online] 119, p.109402. https://doi.org/10.1016/j.jnutbio.2023.109402.
Kahn, B.B. and Flier, J.S., 2000. Obesity and insulin resistance. Journal of Clinical Investigation, [online] 106(4), pp.473–481. https://doi.org/10.1172/jci10842.
Kant, R., Verma, V., Patel, S., Chandra, R., Chaudhary, R., Shuldiner, A.R. and Munir, K.M., 2021. Effect of serum zinc and copper levels on insulin secretion, insulin resistance and pancreatic β cell dysfunction in US adults: Findings from the National Health and Nutrition Examination Survey (NHANES) 2011–2012. Diabetes Research and Clinical Practice, [online] 172, p.108627. https://doi.org/10.1016/j.diabres.2020.108627.
Kaye, T.B., Guay, A.T. and Simonson, D.C., 1993. Non-insulin-dependent diabetes mellitus and elevated serum ferritin level. Journal of Diabetes and its Complications, [online] 7(4), pp.245–249. https://doi.org/10.1016/s0002-9610(05)80252-1.
Kohgo, Y., Ikuta, K., Ohtake, T., Torimoto, Y., & Kato, J. (2007). Iron overload and cofactors with special reference to alcohol, hepatitis C virus infection and steatosis/insulin resistance. World Journal of Gastroenterology : WJG, 13(35), 4699-4706.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611191/
Laakso, M., 1993. How Good a Marker Is Insulin Level for Insulin Resistance? American Journal of Epidemiology, [online] 137(9), pp.959–965. https://doi.org/10.1093/oxfordjournals.aje.a116768.
Lee, S.-H., Park, S.-Y. and Choi, C.S., 2022. Insulin Resistance: From Mechanisms to Therapeutic Strategies. Diabetes & Metabolism Journal, [online] 46(1), pp.15–37. https://doi.org/10.4093/dmj.2021.0280.
Mendler, M.H., Turlin, B., Moirand, R., Jouanolle, A.M., Sapey, T., Guyader, D., Le Gall, J.Y., Brissot, P., David, V. and Deugnier, Y., 1999. Insulin resistance-associated hepatic iron overload. Gastroenterology, [online] 117(5), pp.1155-63. https://doi.org/10.1016/s0016-5085(99)70401-4.
Menezes-Santos, M., Santos, B. da C., Santos, R.K.F., da Costa, S.S.L., dos Santos, S.H., e Silva, A.M. de O., Rocha, V. de S. and Pires, L.V., 2024. Copper Deficiency Associated with Glycemic Control in Individuals with Type 2 Diabetes Mellitus. Biological Trace Element Research. [online] https://doi.org/10.1007/s12011-024-04185-6.
Petersen, K.F. and Shulman, G.I., 2006. Etiology of Insulin Resistance. The American Journal of Medicine, [online] 119(5), pp.S10–S16. https://doi.org/10.1016/j.amjmed.2006.01.009.
Petersen, M.C. and Shulman, G.I., 2018. Mechanisms of Insulin Action and Insulin Resistance. Physiological Reviews, [online] 98(4), pp.2133–2223. https://doi.org/10.1152/physrev.00063.2017.
Reaven, G.M., 1988. Role of Insulin Resistance in Human Disease. Diabetes, [online] 37(12), pp.1595–1607. https://doi.org/10.2337/diab.37.12.1595.
Reaven, G.M., 2003. The insulin resistance syndrome. Current Atherosclerosis Reports, [online] 5(5), pp.364–371. https://doi.org/10.1007/s11883-003-0007-0.
Schinner, S., Scherbaum, W.A., Bornstein, S.R. and Barthel, A., 2005. Molecular mechanisms of insulin resistance. Diabetic Medicine, [online] 22(6), pp.674–682. https://doi.org/10.1111/j.1464-5491.2005.01566.x.
Shoelson, S.E., 2006. Inflammation and insulin resistance. Journal of Clinical Investigation, [online] 116(7), pp.1793–1801. https://doi.org/10.1172/jci29069.
Sesti, G., 2006. Pathophysiology of insulin resistance. Best Practice & Research Clinical Endocrinology & Metabolism, [online] 20(4), pp.665–679. https://doi.org/10.1016/j.beem.2006.09.007.
Shulman, G.I., 2000. Cellular mechanisms of insulin resistance. Journal of Clinical Investigation, [online] 106(2), pp.171–176. https://doi.org/10.1172/jci10583.
Song, M., Vos, M. B., & McClain, C. J. (2018). Copper-Fructose Interactions: A Novel Mechanism in the Pathogenesis of NAFLD. Nutrients, 10(11).
https://doi.org/10.3390/nu10111815
Tan, P.Y. and Soma Roy, M., 2021. Dietary copper and selenium are associated with insulin resistance in overweight and obese Malaysian adults. Nutrition Research, [online] 93, pp.38–47. https://doi.org/10.1016/j.nutres.2021.06.008.
Tuomainen, T.-P., Nyyssönen, K., Salonen, R., Tervahauta, A., Korpela, H., Lakka, T., Kaplan, G.A. and Salonen, J.T., 1997. Body Iron Stores Are Associated With Serum Insulin and Blood Glucose Concentrations: Population study in 1,013 eastern Finnish men. Diabetes Care, [online] 20(3), pp.426–428. https://doi.org/10.2337/diacare.20.3.426.
Wallace, T.M. and Matthews, D.R., 2002. The assessment of insulin resistance in man. Diabetic Medicine, [online] 19(7), pp.527–534. https://doi.org/10.1046/j.1464-5491.2002.00745.x.
Wilcox, G., 2005. Insulin and insulin resistance. Clin Biochem Rev, [online] 26(2), pp.19-39. PMID: 16278749; PMCID: PMC1204764.
Zhang, M., Zhang, C., Zhang, X., Li, J., Zhao, J., Xu, X., Liu, Y. and Chen, J., 2020. Relationship between serum iron levels and insulin resistance in type 2 diabetes patients. Diabetes Research and Clinical Practice, [online] 165, p.108231. https://doi.org/10.1016/j.diabres.2020.108231.
Allergy-Friendly Pets
Key Highlights Hypoallergenic pets are great for people with pet allergies, as they produce fewer allergens like dander, saliva, and proteins that can trigger symptoms….
Vegetable Oil: Health Risks You Might Not Know
Key Takeaways: Omega-6 fats from vegetable oils cause oxidative stress and inflammation. Reducing omega-6 intake and using stable fats can lower health risks. High triglycerides…
Proteolytic Enzymes and Heart Health: What the Research Shows
Your heart works tirelessly to pump blood throughout your body, delivering essential nutrients and oxygen to your cells. However, factors like poor diet, stress, and…
Signs of Diabetes: Recognizing the Red Flags
Key Takeaways Increased Thirst and Urination: High blood sugar leads to dehydration, causing excessive thirst and frequent urination. Unexplained Weight Loss: Diabetes can cause the…
Atherosclerosis Prevention Strategies: Insights from Scientific Research
Key Takeaways Atherosclerosis is the hardening and narrowing of arteries caused by plaque buildup. Chronic inflammation and oxidative stress contribute to the development of plaque….
7 Remedies for Kidney Stones: A Comprehensive Guide
Key Takeaways Staying well-hydrated and adopting a balanced diet can help prevent kidney stones. Knowing the causes of kidney stones can inform effective prevention strategies….
Coping with Pet Allergies: Tips & Advice
Key Highlights Pet allergies often cause sneezing, coughing, itchy eyes, and skin rash. Pet allergens are in the saliva, urine, and dander of furry animals….
SIBO Bloating: Causes, Diet, & Management Tips
Key Takeaways SIBO disrupts gut bacteria balance, causing bloating, pain, and nutrient absorption issues. Symptoms include bloating, abdominal pain, diarrhea, constipation, weight loss, and fatigue….
Postbiotics: What They Are and Why They Are Important
Key Takeaways Postbiotics 101: They’re beneficial by-products from probiotics that consume prebiotics Boosts Immunity: Postbiotics sharpen your immune system, helping fight off pathogens and reducing…
Alcohol and Its Effects
Key Takeaways Alcohol is metabolized primarily in the liver, producing acetaldehyde, a toxic byproduct. Chronic alcohol consumption leads to liver damage, including fatty liver, hepatitis,…
L-Glutamine and Gut Health: Benefits and Side Effects
Key Takeaways L-Glutamine is essential for gut health. Benefits include improved digestion and reduced inflammation. Potential side effects are rare but can occur in high…
Remnant Cholesterol (RC): Its Origins & Impact
Key Takeaways Remnant cholesterol (RC) is the cholesterol content left in the blood after triglycerides are removed from VLDL and IDL particles. RC is a…
7 Simple Tips for Lowering Blood Pressure Naturally
Maintaining healthy blood pressure levels is essential for overall well-being, as high blood pressure can lead to serious health complications. However, it is possible to…
How to Lower Triglycerides Fast: Natural Solutions
Key Highlights Triglycerides, a type of fat found in the blood, are essential indicators of metabolic health. Elevated triglyceride levels increase the risk of heart…
Metabolic Syndrome: Managing This Health Risk
Key Takeaways Metabolic syndrome is a cluster of conditions increasing the risk of heart disease, stroke, and diabetes. Symptoms include high blood pressure, high blood…
Parkinson’s Disease : Symptoms, Causes & Treatment
Key Takeaways Parkinson’s disease is a progressive neurological disorder that affects movement and coordination. Oxidative stress and excess iron are significant factors in the progression…
Non-Alcoholic Fatty Liver Disease (NAFLD)
Key Takeaways NAFLD involves fat buildup in the liver not caused by alcohol. Commonly associated with obesity, insulin resistance, and metabolic syndrome. NAFLD can lead…
Iron Overload: Symptoms & Prevention Tips
Key Takeaways: Iron overload happens when the body absorbs excessive iron, which can damage organs. Common symptoms include fatigue, joint pain, and skin changes. Early…
Travel Hygiene Tips: Stay Fresh on the Go
Key Highlights Key practices include frequent handwashing, showering, and oral care. Packing a portable hygiene kit can help you stay fresh on the go. Advanced…
Chronic Kidney Disease (CKD): Causes & Treatment
Key Takeaways Ultra-processed foods and high carbohydrate intake worsen inflammation, harming kidney function. Iron overload leads to oxidative stress, which accelerates CKD progression. Copper is…
Uric Acid: Effects & Management
Triglycerides: Levels & Range Explained
Key Highlights Triglycerides are the most common form of fat in the body play a role in energy storage High levels of triglycerides can increase…
High Homocysteine: How to Manage Levels
Key Takeaways: Elevated homocysteine can raise the risk of heart disease and other health problems. Animal-based foods high in B vitamins help reduce homocysteine levels….
Supporting Mental Health with Gut Health
Key Takeaways Gut-Brain Connection: Gut health is directly linked to mental wellbeing through the gut-brain axis. Probiotics: Beneficial bacteria that help regulate mood and support…
Is Eating Sugar Really That Bad For Your Health?
Should You Really Be Concerned? In short, YES! Thank you, that’s all folks, and do have a good evening. Seriously though, extensive research has established…
Histamine: What You Should Know
Key Takeaways Histamine’s Role: Vital in immune responses, digestion, and as a neurotransmitter in the central nervous system. Histamine Production: Produced in mast cells and…
Diabetes: Everything You Need to Know
Key Takeaways Type 1 and Type 2 diabetes involve insulin regulation issues, with Type 2 being the most common due to insulin resistance. Copper, retinol,…
Inflammation: Causes & Effects
Key Takeaways Inflammation is the body’s response to injury or infection, but chronic inflammation can lead to health problems. Iron overload from artificial sources and…
Dialysis: Benefits & Challenges
Key Takeaways Dialysis removes waste and excess fluid from the blood when kidneys cannot function. Two main types: hemodialysis (machine-based) and peritoneal dialysis (abdomen-based). Dialysis…
Boost Insulin Sensitivity Naturally
Key Takeaways Improving insulin sensitivity helps control blood sugar and reduces the risk of metabolic disorders. Regular physical activity enhances how cells respond to insulin….
Alzheimer’s Disease: Symptoms, Causes, Treatment
Key Takeaways Alzheimer’s disease is a progressive neurodegenerative disorder affecting memory, thinking, and behavior. Oxidative stress, including from excess iron, plays a significant role in…
Metabolic Health: What It Means and How to Improve It
Key Takeaways Metabolic health reflects how well your body processes energy and maintains stable blood sugar, cholesterol, and blood pressure. Key indicators of metabolic health…
Quit Sugar for 14 Days: What Happens to Your Body?
Key Takeaways: Immediate Health Benefits of Reducing Sugar: In just two weeks, enjoy enhanced energy levels, weight loss, a reduced risk of chronic diseases, and…