Bromate: Its Impact on Your Thyroid & Nervous System

Key Takeaways

  • Bromate is a toxic byproduct from water disinfection, impacting thyroid and nervous system health.
  • It interferes with iodine, leading to thyroid dysfunction and potential hypothyroidism.
  • High bromate exposure can cause oxidative stress and neurotoxicity.
  • Bromine, related to bromate, is found in industrial products and also poses health risks.
  • Reducing bromate exposure through water filtration and proper iodine intake is important.

What is Bromate?

bromate

Bromate is a chemical compound that forms during the disinfection of water, particularly when ozone is used to treat bromide-containing water.

It can also be present in certain baked goods, where potassium bromate is used as a flour improver.

While bromate is useful in industrial processes, it poses significant health risks, particularly to the thyroid and nervous systems.

Bromate’s Impact on Health

thyroid

Thyroid

Bromate disrupts thyroid function by interfering with the uptake of iodine, which is essential for the production of thyroid hormones.

This can cause various symptoms, including fatigue, weight gain, and depression.

This interference can lead to thyroid disorders, such as hypothyroidism and goiter, where the thyroid gland enlarges due to inadequate hormone production.

Thyroid Disorders Linked to Bromate

Continued exposure to bromate increases the risk of developing thyroid disorders. Hypothyroidism is common, where insufficient thyroid hormones are produced, leading to a slow metabolism.

Goiter, an enlargement of the thyroid gland, may also occur due to iodine deficiency aggravated by bromate exposure.

Reducing Bromate’s Impact on the Thyroid

To minimize bromate’s effects on the thyroid, it’s important to ensure adequate iodine intake through diet.

Additionally, filtering drinking water can help reduce bromate exposure, as it is commonly introduced through water treatment processes.

Nervous System

Beyond the thyroid, bromate also affects the nervous system. It can lead to oxidative stress, damaging cells and tissues in the brain, which may result in cognitive impairments and other neurological issues.

Bromine

While the focus is on bromate, it’s worth noting that bromine, a related compound, is also present in various industrial products like flame retardants and certain medications.

Bromine shares similar health risks, disrupting thyroid and nervous system functions.

Cancer

High levels of potassium bromate in bread present health risks, including cancer, to consumers worldwide. Bakers exposed to it may experience symptoms like sore throat, cough, and eye irritation.

Polybrominated diphenyl ethers (PBDEs) are flame retardants linked to hormonal disruptions, developmental issues, and cancer. Humans are exposed mainly through dust ingestion and diet, with higher levels reported in regions with PBDE production and e-waste recycling

Managing Bromate Exposure

filtered water

Reducing exposure to bromate is vital for protecting both the thyroid and nervous system.

This can be achieved by filtering drinking water, avoiding foods with added bromate, and ensuring sufficient iodine intake.

Reducing Bromate Intake

To limit bromate exposure, use water filters designed to remove bromate and avoid consuming products that may contain bromate, such as certain baked goods and bottled water from non-regulated sources.

Iodine Supplementation

Iodine supplementation can help mitigate bromate’s effects on the thyroid by ensuring that the gland has enough iodine to produce essential hormones.

This is particularly important for individuals at risk of high bromate exposure.

FAQ

What are the main sources of bromate exposure?
Bromate is commonly found in treated drinking water and some baked goods where potassium bromate is used.

How does bromate affect the thyroid and nervous system?
Bromate interferes with iodine uptake, disrupting thyroid hormone production and leading to potential thyroid disorders. It also causes oxidative stress in the nervous system, leading to cognitive and neurological issues.

Can iodine supplements help mitigate bromate’s effects?
Yes, iodine supplements can help ensure that the thyroid has enough iodine to function properly, countering bromate’s interference.

What are the symptoms of bromate toxicity?
Symptoms include thyroid dysfunction, such as hypothyroidism and goiter, as well as neurological symptoms like memory loss and cognitive decline.

How can I reduce bromate exposure in my daily life?
Filter your drinking water, avoid products with added bromate, and ensure you consume enough iodine to protect against its effects.

Research



Beane Freeman, L.E., Kogevinas, M., Cantor, K.P., Villanueva, C.M., Prokunina-Olsson, L., Florez-Vargas, O., Figueroa, J.D., Ward, M.H., Koutros, S., Baris, D., Garcia-Closas, M., Schwenn, M., Johnson, A., Serra, C., Tardon, A., Garcia-Closas, R., Carrato, A., Malats, N., Karagas, M.R., Rothman, N. and Silverman, D.T. (2022). Disinfection By-Products in Drinking Water and Bladder Cancer: Evaluation of Risk Modification by Common Genetic Polymorphisms in Two Case–Control Studies. Environmental Health Perspectives, [online] 130(5). https://doi.org/10.1289/ehp9895.

Bramwell, L., Glinianaia, S.V., Rankin, J., Rose, M., Fernandes, A., Harrad, S. and Pless-Mulolli, T. (2016). Associations between human exposure to polybrominated diphenyl ether flame retardants via diet and indoor dust, and internal dose: A systematic review. Environment International, [online] 92–93, pp.680–694. https://doi.org/10.1016/j.envint.2016.02.017.

Chhipi-Shrestha, G., Rodriguez, M., & Sadiq, R. (2018). Unregulated disinfection By-products in drinking water in Quebec: A meta analysis. Journal of Environmental Management, 223, 984-1000. https://doi.org/10.1016/j.jenvman.2018.06.082.

Grellier, J., Rushton, L., Briggs, D. J., & Nieuwenhuijsen, M. J. (2015). Assessing the human health impacts of exposure to disinfection by-products — A critical review of concepts and methods. Environment International, 78, 61-81. https://doi.org/10.1016/j.envint.2015.02.003.

Harrad, S. (2015). A meta-analysis of recent data on UK environmental levels of POP-BFRs in an international context: Temporal trends and an environmental budget. Emerging Contaminants, [online] 1(1), pp.39–53. https://doi.org/10.1016/j.emcon.2015.08.001.

Hites, R.A. (2004). Polybrominated Diphenyl Ethers in the Environment and in People: A Meta-Analysis of Concentrations. Environmental Science & Technology, [online] 38(4), pp.945–956. https://doi.org/10.1021/es035082g.

Kawanishi, S., & Murata, M. (2006). Mechanism of DNA damage induced by bromate differs from general types of oxidative stress. Toxicology, 221(2-3), 172-178. https://doi.org/10.1016/j.tox.2006.01.002.

Kodavanti, P. R. S., Stoker, T. E., Fenton, S. E., & Curras-Collazo, M. (2022). Brominated flame retardants. Reproductive and Developmental Toxicology (Third Edition), 691-726. https://doi.org/10.1016/B978-0-323-89773-0.00036-9.

Kurokawa, Y., Maekawa, A., Takahashi, M., and Hayashi, Y. (1990). Toxicity and carcinogenicity of potassium bromate--a new renal carcinogen. Environmental Health Perspectives, [online] 87, pp.309–335. https://doi.org/10.1289/ehp.9087309.

Kumar, A., Rout, S. and Singhal, R.K. (2011). Health Risk Assessment for Bromate (BrO₃⁻) Traces in Ozonated Indian Bottled Water. Journal of Environmental Protection, [online] 02(05), pp.571–580. https://doi.org/10.4236/jep.2011.25066.

Leri, A. C., Hettithanthri, O., Bolan, S., Zhang, T., Unrine, J., Myneni, S., Nachman, D. R., Tran, H. T., Phillips, A. J., Hou, D., Wang, Y., Vithanage, M., Padhye, L. P., Jasemi Zad, T., Heitz, A., Siddique, K. H., Wang, H., Rinklebe, J., Kirkham, M., . . . Bolan, N. (2024). Bromine contamination and risk management in terrestrial and aquatic ecosystems. Journal of Hazardous Materials, 469, 133881. https://doi.org/10.1016/j.jhazmat.2024.133881.

Lyche, J. L., Rosseland, C., Berge, G., & Polder, A. (2015). Human health risk associated with brominated flame-retardants (BFRs). Environment International, 74, 170-180. https://doi.org/10.1016/j.envint.2014.09.006.

Nieuwenhuijsen, M.J., Smith, R., Golfinopoulos, S., Best, N., Bennett, J., Aggazzotti, G., Righi, E., Fantuzzi, G., Bucchini, L., Cordier, S., Villanueva, C.M., Moreno, V., Vecchia, C.L., Bosetti, C., Vartiainen, T., Rautiu, R., Toledano, M., Iszatt, N., Grazuleviciene, R. and Kogevinas, M. (2009). Health impacts of long-term exposure to disinfection by-products in drinking water in Europe: HIWATE. Journal of Water and Health, [online] 7(2), pp.185–207. https://doi.org/10.2166/wh.2009.073.

Ncheuveu Nkwatoh, T., Fon, T.P. and Navti, L.K., 2023. Potassium bromate in bread, health risks to bread consumers and toxicity symptoms amongst bakers in Bamenda, North West Region of Cameroon. Heliyon, [online] 9(2), p.e13146.
https://doi.org/10.1016/j.heliyon.2023.e13146.


Regli, S., Chen, J., Messner, M., Elovitz, M.S., Letkiewicz, F.J., Pegram, R.A., Pepping, T.J., Richardson, S.D. and Wright, J.M. (2015). Estimating Potential Increased Bladder Cancer Risk Due to Increased Bromide Concentrations in Sources of Disinfected Drinking Waters. Environmental Science & Technology, [online] 49(22), pp.13094–13102. https://doi.org/10.1021/acs.est.5b03547.

Renzelli, V., Gallo, M., Morviducci, L., Marino, G., Ragni, A., Tuveri, E., Faggiano, A., Mazzilli, R., Natalicchio, A., Zatelli, M. C., Montagnani, M., Fogli, S., Giuffrida, D., Argentiero, A., Danesi, R., Gori, S., Franchina, T., Russo, A., Monami, M., . . . Silvestris, N. Polybrominated Diphenyl Ethers (PBDEs) and Human Health: Effects on Metabolism, Diabetes and Cancer. Cancers, 15(17), 4237.
https://doi.org/10.3390/cancers15174237

Sharma, V.K., Zboril, R. and McDonald, T.J. (2013). Formation and toxicity of brominated disinfection byproducts during chlorination and chloramination of water: A review. Journal of Environmental Science and Health, Part B, [online] 49(3), pp.212–228. https://doi.org/10.1080/03601234.2014.858576.

Shanmugavel, V., Komala Santhi, K., Kurup, A. H., Kalakandan, S., Anandharaj, A., & Rawson, A. (2020). Potassium bromate: Effects on bread components, health, environment and method of analysis: A review. Food Chemistry, 311, 125964.
https://doi.org/10.1016/j.foodchem.2019.125964

Shen, C., Zhang, K., Shi, J., Yang, J., Wang, Y., Li, Z., Dai, H. and Yang, W. (2024). Association between brominated flame retardants and risk of endocrine-related cancer: A systematic review and meta-analysis. Toxicology Letters, [online] 394, pp.11–22. https://doi.org/10.1016/j.toxlet.2024.02.002.

Wagner, H. P., Pepich, B. V., Hautman, D. P., & Munch, D. J. (2000). Eliminating the chlorite interference in US Environmental Protection Agency Method 317.0 permits analysis of trace bromate levels in all drinking water matrices. Journal of Chromatography A, 882(1-2), 309-319. https://doi.org/10.1016/S0021-9673(00)00306-X.

Wu, Z., He, C., Han, W., Song, J., Li, H., Zhang, Y., Jing, X. and Wu, W. (2020). Exposure pathways, levels and toxicity of polybrominated diphenyl ethers in humans: A review. Environmental Research, [online] 187, p.109531. https://doi.org/10.1016/j.envres.2020.109531.

Zhao, X., Wang, H., Li, J., Shan, Z., Teng, W., & Teng, X. (2015). The Correlation between Polybrominated Diphenyl Ethers (PBDEs) and Thyroid Hormones in the General Population: A Meta-Analysis. PLOS ONE, 10(5), e0126989. https://doi.org/10.1371/journal.pone.0126989.
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