Key Takeaways
- Oxidative stress results from an imbalance between free radicals and antioxidants in the body, leading to cellular damage.
- Chronic oxidative stress contributes to diseases such as cancer, cardiovascular conditions, and neurodegenerative disorders.
- Poor diet, smoking, and exposure to environmental pollutants significantly contribute to oxidative stress.
- Managing oxidative stress involves increasing antioxidant intake, adopting a healthy lifestyle, and reducing exposure to toxins.
- Consuming antioxidant-rich foods, regular exercise, and avoiding processed foods effectively combat oxidative stress.
Introduction to Oxidative Stress
Oxidative stress occurs when free radicals outnumber antioxidants in the body. Free radicals are unstable molecules that cause cellular damage, while antioxidants neutralize them.
An imbalance between the two leads to oxidative stress, which plays a role in aging and disease development.
Causes of Oxidative Stress
Environmental pollutants, smoking, poor diet, and psychological stress increase free radical production.
Natural biological processes, like metabolism and aging, also contribute to oxidative stress over time.
Iron
While necessary for life, iron can also be a source of harm when present in excess or when it is not properly managed.
This harmful side of iron emerges when it contributes to oxidative stress—a process that can lead to significant cellular damage and a range of chronic health issues.
Iron and Free Radical Production
Iron contributes to oxidative stress through its involvement in the Fenton reaction, a chemical process that produces reactive oxygen species (ROS).
ROS are highly reactive molecules that can damage cellular structures, including DNA, proteins, and lipids.
This damage disrupts normal cellular functions and can trigger a cascade of negative health effects, including inflammation and the development of chronic diseases.
Iron Regulation and Oxidative Stress
Hepcidin is a peptide hormone that plays a central role in regulating iron levels in the body. During times of inflammation, the production of hepcidin increases, leading to reduced iron absorption from the diet and trapping of iron within cells.
This iron retention, while a natural defense mechanism against infections, can lead to an excess buildup of iron in tissues, contributing to oxidative stress and tissue damage.
Copper and Ceruloplasmin
Copper is an essential mineral that, through its involvement with ceruloplasmin, regulates iron metabolism.
Ceruloplasmin is a protein that facilitates the safe transport and storage of iron by oxidizing ferrous iron (Fe2+) to its less reactive ferric form (Fe3+), preventing it from contributing to oxidative stress.
When there is a deficiency in bioavailable copper, ceruloplasmin activity diminishes, leading to iron dysregulation and an increased risk of oxidative stress.
Effects of Oxidative Stress on the Body
Oxidative stress accelerates aging and damages cells, proteins, and DNA. It’s linked to cardiovascular diseases, cancer, neurodegenerative diseases like Alzheimer’s, and diabetes.
Health Complications
Autoimmune Diseases:
The oxidative stress caused by iron can damage tissues and organs, triggering abnormal immune responses where the body attacks its own cells.
Cardiovascular Diseases:
Excess iron can promote the formation of arterial plaques, leading to conditions like atherosclerosis, heart attacks, and strokes.
Neurodegenerative Disorders:
The brain is particularly vulnerable to oxidative stress due to its high oxygen consumption and abundance of easily oxidized fats.
Iron accumulation in the brain has been associated with neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease, where oxidative stress contributes to the progressive loss of neuronal function.
Symptoms and Indicators of Oxidative Stress
Common symptoms include fatigue, memory loss, and premature aging. Biomarkers like 8-hydroxydeoxyguanosine (8-OHdG) and malondialdehyde (MDA) can measure oxidative stress levels.
Strategies to Mitigate Oxidative Stress
Increasing antioxidant intake through diet, engaging in regular exercise, and reducing exposure to toxins are key strategies.
Antioxidant-rich foods include organ meats, fatty fish, berries, leafy greens, and nuts.
Regular physical activity boosts antioxidant defenses, while stress management techniques like meditation help lower oxidative stress levels.
Role of Antioxidants in Combating Oxidative Stress
Antioxidants neutralize free radicals. Key antioxidants include vitamins C and E, glutathione, and selenium.
These can be found in liver, eggs, fish, fruits, vegetables, and nuts.
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Ketosis Suppression and Ageing (KetoSAge) Part 2: The Effect of Suppressing Ketosis on Biomarkers Associated with Ageing, HOMA-IR, Leptin, Osteocalcin, and GLP-1, in Healthy Females
Metabolic dysfunctions are among the best documented… pic.twitter.com/wjSrhvC737
Medical and Supplement Interventions
Antioxidant supplements, such as whole food vitamin C complex, vitamin E, and coenzyme Q10, can help manage oxidative stress.
Conclusion
Maintaining a balance between free radicals and antioxidants is essential for health. Simple lifestyle and dietary changes can help mitigate oxidative stress and its associated risks.Consulting with a healthcare provider ensures the best approach to supplementation.
FAQ
What is oxidative stress and why is it harmful?
Oxidative stress is an imbalance between free radicals and antioxidants, leading to cellular damage and various diseases.
What are common causes of oxidative stress?
Environmental pollutants, poor diet, smoking, excessive alcohol consumption, and psychological stress are common causes.
How can I reduce oxidative stress in my body?
Adopting a diet rich in antioxidants, regular exercise, reducing exposure to toxins, and managing stress can help reduce oxidative stress.
What foods are high in antioxidants?
Animal foods like organ meats and fatty fish, along with fruits, vegetables, and nuts, are high in antioxidants.
Can supplements help with oxidative stress?
Antioxidant supplements may help, but it’s best to consult a healthcare provider for personalized advice.
Research
Batey RG, Lai Chung Fong P, Shamir S, Sherlock S. A non-transferrin-bound serum iron in idiopathic hemochromatosis. Dig Dis Sci. 1980 May;25(5):340-6. doi: 10.1007/BF01308057. PMID: 7371472.
Bo, S., Durazzo, M., Gambino, R., Berutti, C., Milanesio, N., Caropreso, A., Gentile, L., Cassader, M., Cavallo-Perin, P. and Pagano, G., 2008. Associations of Dietary and Serum Copper with Inflammation, Oxidative Stress, and Metabolic Variables in Adults ,. The Journal of Nutrition, [online] 138(2), pp.305–310. https://doi.org/10.1093/jn/138.2.305.
Boddaert, N., Le Quan Sang, K. H., Rötig, A., Leroy-Willig, A., Gallet, S., Brunelle, F., Sidi, D., Thalabard, J., Munnich, A., & Cabantchik, Z. I. (2007). Selective iron chelation in Friedreich ataxia: Biologic and clinical implications. Blood, 110(1), 401-408. https://doi.org/10.1182/blood-2006-12-065433
DiNicolantonio, J.J., Mangan, D. and O’Keefe, J.H., 2018. The fructose–copper connection: Added sugars induce fatty liver and insulin resistance via copper deficiency. Journal of Metabolic Health, [online] 3(1).
https://doi.org/10.4102/jir.v3i1.43.
Fillebeen, C., Descamps, L., Dehouck, M.-P., Fenart, L., Benaïssa, M., Spik, G., Cecchelli, R. and Pierce, A., 1999. Receptor-mediated Transcytosis of Lactoferrin through the Blood-Brain Barrier. Journal of Biological Chemistry, [online] 274(11), pp.7011–7017. https://doi.org/10.1074/jbc.274.11.7011.
Gaetke, L., 2003. Copper toxicity, oxidative stress, and antioxidant nutrients. Toxicology, [online] 189(1–2), pp.147–163. https://doi.org/10.1016/s0300-483x(03)00159-8.
Galaris, D., Barbouti, A. and Pantopoulos, K., 2019. Iron homeostasis and oxidative stress: An intimate relationship. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, [online] 1866(12), p.118535. https://doi.org/10.1016/j.bbamcr.2019.118535.
Greenberg, G.R. and Wintrobe, M.M., 1946. A LABILE IRON POOL. Journal of Biological Chemistry, [online] 165(1), pp.397–398. https://doi.org/10.1016/s0021-9258(17)41250-6.
Gutteridge, J.M.C. and Halliwell, B., 2018. Mini-Review: Oxidative stress, redox stress or redox success? Biochemical and Biophysical Research Communications, [online] 502(2), pp.183–186.
https://doi.org/10.1016/j.bbrc.2018.05.045.
Hentze, M.W., Muckenthaler, M.U., Galy, B. and Camaschella, C., 2010. Two to Tango: Regulation of Mammalian Iron Metabolism. Cell, [online] 142(1), pp.24–38. https://doi.org/10.1016/j.cell.2010.06.028.
Ke, Y. and Qian, Z.M., 2007. Brain iron metabolism: Neurobiology and neurochemistry. Progress in Neurobiology, [online] 83(3), pp.149–173. https://doi.org/10.1016/j.pneurobio.2007.07.009.
Kenkhuis, B., Bush, A.I. and Ayton, S., 2023. How iron can drive neurodegeneration. Trends in Neurosciences, [online] 46(5), pp.333–335.
https://doi.org/10.1016/j.tins.2023.02.003.
Kruszewski, M., 2003. Labile iron pool: the main determinant of cellular response to oxidative stress. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, [online] 531(1–2), pp.81–92.
https://doi.org/10.1016/j.mrfmmm.2003.08.004.
Milanino, R., Conforti, A., Franco, L., Marrella, M. and Velo, G., 1985. Review: Copper and inflammation — a possible rationale for the pharmalogical manipulation of inflammatory discorders. Agents and Actions, [online] 16(6), pp.504–513. https://doi.org/10.1007/bf01983655.
Mills, E., Dong, X., Wang, F. and Xu, H., 2009. Mechanisms of Brain Iron Transport: Insight into Neurodegeneration and CNS Disorders. Future Medicinal Chemistry, [online] 2(1), pp.51–64. https://doi.org/10.4155/fmc.09.140.
Moos T., Morgan EH. Transferrin and transferrin receptor function in brain barrier systems. Cell Mol Neurobiol. 2000 Feb;20(1):77-95. doi: 10.1023/a:1006948027674. PMID: 10690503.
Moos, T., Nielsen, T.R., Skjørringe, T. and Morgan, E.H., 2007. Iron trafficking inside the brain. Journal of Neurochemistry, [online] 103(5), pp.1730–1740. https://doi.org/10.1111/j.1471-4159.2007.04976.x.
Muckenthaler MU, Galy B, Hentze MW. Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network. Annu Rev Nutr. 2008;28:197-213. doi: 10.1146/annurev.nutr.28.061807.155521. PMID: 18489257.
Sorenson, J.R.J., 1989. 6 Copper Complexes Offer a Physiological Approach to Treatment of Chronic Diseases. Progress in Medicinal Chemistry, [online] pp.437–568. https://doi.org/10.1016/s0079-6468(08)70246-7.
Uriu-Adams, J.Y. and Keen, C.L., 2005. Copper, oxidative stress, and human health. Molecular Aspects of Medicine, [online] 26(4–5), pp.268–298. https://doi.org/10.1016/j.mam.2005.07.015.
Wang, J. and Pantopoulos, K., 2011. Regulation of cellular iron metabolism. Biochemical Journal, [online] 434(3), pp.365–381. https://doi.org/10.1042/bj20101825.
Wallander, M.L., Leibold, E.A. and Eisenstein, R.S., 2006. Molecular control of vertebrate iron homeostasis by iron regulatory proteins. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, [online] 1763(7), pp.668–689. https://doi.org/10.1016/j.bbamcr.2006.05.004.
Ward, R.J., Zucca, F.A., Duyn, J.H., Crichton, R.R. and Zecca, L., 2014. The role of iron in brain ageing and neurodegenerative disorders. The Lancet Neurology, [online] 13(10), pp.1045–1060.
https://doi.org/10.1016/s1474-4422(14)70117-6.
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