TUDCA Benefits for Health

Key Takeaways

  • TUDCA supports liver health and detoxification.
  • It improves bile flow and digestion.
  • TUDCA has neuroprotective properties.
  • It aids in managing metabolic disorders.
  • TUDCA supports overall cellular health.

Liver Health and Detoxification

TUDCA (tauroursodeoxycholic acid) is a bile acid derivative known for its liver health benefits. It detoxifies the liver, promoting the elimination of toxic bile acids.

This protection reduces the risk of liver diseases like cirrhosis and hepatitis.

Improved Bile Flow and Digestion

TUDCA enhances bile flow, aiding the emulsification and absorption of dietary fats and fat-soluble vitamins.

Improved bile flow also helps prevent the formation of gallstones.

Neuroprotective Properties

TUDCA Benefits for Health

Research indicates that TUDCA offers neuroprotective effects, benefiting brain health. It reduces cell death and inflammation in the brain, which is valuable for managing conditions like Alzheimer’s, Parkinson’s, and other neurodegenerative diseases.

Reduction in endoplasmic reticulum stress plays a significant role in its neuroprotective properties.

Managing Metabolic Disorders

TUDCA helps manage metabolic disorders, including diabetes and obesity.

It improves insulin sensitivity and reduces inflammation, critical for controlling blood sugar levels and maintaining a healthy weight. Enhanced liver function also supports overall metabolic health.

Cellular Health Support

red blood cell

TUDCA supports cellular health by protecting cells from apoptosis (programmed cell death) and reducing oxidative stress. This protection is crucial for maintaining healthy tissues and organs.

TUDCA’s ability to stabilize cellular membranes and improve mitochondrial function further enhances its role in promoting overall cellular health.

Conclusion

TUDCA offers a wide range of health benefits, particularly for liver health, digestion, brain protection, and managing metabolic disorders. Its ability to support cellular health makes it a valuable supplement for overall well-being.

FAQs

What is TUDCA?
TUDCA (tauroursodeoxycholic acid) is a bile acid derivative known for its liver-protective properties.

How does TUDCA improve liver health?
TUDCA promotes the elimination of toxic bile acids, protecting liver cells and reducing the risk of
liver diseases.

Can TUDCA help with digestion?
Yes, TUDCA enhances bile flow, aiding in the digestion and absorption of fats and fat-soluble vitamins.

Is TUDCA beneficial for brain health?
TUDCA has neuroprotective properties, reducing cell death and inflammation in the brain, beneficial for
neurodegenerative conditions.

Can TUDCA help with metabolic disorders?
TUDCA improves insulin sensitivity and reduces inflammation, supporting the management of diabetes
and obesity.

Research


Albanese, A., Ludolph, A. C., McDermott, C. J., Corcia, P., Van Damme, P., H., L., Hardiman, O., Rinaldi, G., Vanacore, N., Dickie, B., Group, A. S., Tornese, P., Cocco, A., Giudice, M. L., Matteoli, M., Lauranzano, E., Malosio, M. L., Adriana Elia, C., Lombardo, F., . . . Obáin, N. N. (2022). Tauroursodeoxycholic acid in patients with amyotrophic lateral sclerosis: The TUDCA-ALS trial protocol. Frontiers in Neurology, 13, 1009113. https://doi.org/10.3389/fneur.2022.1009113

Berger, E., & Haller, D. (2011). Structure–function analysis of the tertiary bile acid TUDCA for the resolution of endoplasmic reticulum stress in intestinal epithelial cells. Biochemical and Biophysical Research Communications, 409(4), 610-615. https://doi.org/10.1016/j.bbrc.2011.05.043

Cabrera, D., Arab, J.P., Arrese, M. (2019). UDCA, NorUDCA, and TUDCA in Liver Diseases: A Review of Their Mechanisms of Action and Clinical Applications. In: Fiorucci, S., Distrutti, E. (eds) Bile Acids and Their Receptors. Handbook of Experimental Pharmacology, vol 256. Springer, Cham. 
https://doi.org/10.1007/164_2019_241

Cardoso, I., Martins, D., Ribeiro, T. et al. Synergy of combined Doxycycline/TUDCA treatment in lowering Transthyretin deposition and associated biomarkers: studies in FAP mouse models. J Transl Med 8, 74 (2010). https://doi.org/10.1186/1479-5876-8-74

Lee, Y. Y., Hong, S. H., Lee, Y. J., Chung, S. S., Jung, H. S., Park, S. G., & Park, K. S. (2010). Tauroursodeoxycholate (TUDCA), chemical chaperone, enhances function of islets by reducing ER stress. Biochemical and Biophysical Research Communications, 397(4), 735-739. https://doi.org/10.1016/j.bbrc.2010.06.022

Lu, Q., Jiang, Z., Wang, Q., Hu, H., & Zhao, G. (2021). The effect of Tauroursodeoxycholic acid (TUDCA) and gut microbiota on murine gallbladder stone formation. Annals of Hepatology, 23, 100289. https://doi.org/10.1016/j.aohep.2020.100289

Ma, H., Zeng, M., Han, Y., Yan, H., Tang, H., Sheng, J., Hu, H., Cheng, L., Xie, Q., Zhu, Y., Chen, G., Gao, Z., Xie, W., Wang, J., Wu, S., Wang, G., Miao, X., Fu, X., Duan, L., Xu, J., Wei, L., Shi, G., Chen, C., Chen, M., Ning, Q., Yao, C. and Jia, J., 2016. A multicenter, randomized, double-blind trial comparing the efficacy and safety of TUDCA and UDCA in Chinese patients with primary biliary cholangitis. Medicine, [online] 95(47), p.e5391. 
https://pubmed.ncbi.nlm.nih.gov/27893675/.

Mantopoulos, D., Murakami, Y., Comander, J., Thanos, A., Roh, M., Miller, J. W., & Vavvas, D. G. (2011). Tauroursodeoxycholic Acid (TUDCA) Protects Photoreceptors from Cell Death after Experimental Retinal Detachment. PLOS ONE, 6(9), e24245. 
https://doi.org/10.1371/journal.pone.0024245

Nunes, A.F., Amaral, J.D., Lo, A.C., Fonseca, M.B., Viana, R.J.S., Callaerts-Vegh, Z., D’Hooge, R. and Rodrigues, C.M.P., 2012. TUDCA, a Bile Acid, Attenuates Amyloid Precursor Protein Processing and Amyloid-β Deposition in APP/PS1 Mice. Molecular Neurobiology, [online] 45(3), pp.440–454. https://doi.org/10.1007/s12035-012-8256-y.

Noailles, A., Fernández-Sánchez, L., Lax, P. et al. Microglia activation in a model of retinal degeneration and TUDCA neuroprotective effects. J Neuroinflammation 11, 186 (2014). https://doi.org/10.1186/s12974-014-0186-3

Oveson, B. C., Iwase, T., Hackett, S. F., Lee, S. Y., Usui, S., Sedlak, T. W., Snyder, S. H., Campochiaro, P. A., & Sung, J. U. (2011). Constituents of bile, bilirubin and TUDCA, protect against oxidative stress-induced retinal degeneration. Journal of Neurochemistry, 116(1), 144-153. https://doi.org/10.1111/j.1471-4159.2010.07092.x

Rani, S., Sreenivasaiah, P. K., Kim, J. O., Lee, M. Y., Kang, W. S., Kim, Y. S., Ahn, Y., Park, W. J., Cho, C., & Kim, D. H. (2017). Tauroursodeoxycholic acid (TUDCA) attenuates pressure overload-induced cardiac remodeling by reducing endoplasmic reticulum stress. PLOS ONE, 12(4), e0176071. https://doi.org/10.1371/journal.pone.0176071

Yanguas-Casás, N., Barreda-Manso, M. A., Nieto-Sampedro, M., & Romero-Ramírez, L. (2017). TUDCA: An Agonist of the Bile Acid Receptor GPBAR1/TGR5 With Anti-Inflammatory Effects in Microglial Cells. Journal of Cellular Physiology, 232(8), 2231-2245. https://doi.org/10.1002/jcp.25742

Zangerolamo, L., Vettorazzi, J.F., Rosa, L.R., Carneiro, E.M. and Barbosa, H.C., 2021. The bile acid TUDCA and neurodegenerative disorders: An overview. Life sciences, 272, p.119252.
Spread the love

Leave a Comment

Your email address will not be published. Required fields are marked *

Explore More

Legal Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products found on the website are not intended to diagnose, treat, cure, or prevent any disease. The information contained herein is for informational purposes only and does not establish a doctor-patient relationship. Please be sure to consult your physician before taking these or any other health-related interventions. Affiliate Disclaimer: openintegrative.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to (“openintegrative.com” (amazon.com, or endless.com, MYHABIT.com, SmallParts.com, or AmazonWireless.com).

Copyright © 2024 Open Integrative. All rights reserved.

Scroll to Top