Key Takeaways
- Dialysis cleans waste and extra fluid when damaged kidneys cannot keep blood safe.
- Treatment can ease swelling, breath trouble, nausea and dangerous mineral shifts.
- Dialysis can help you live longer, but it cannot fully copy healthy kidneys.
- The main burdens include time, tiredness, access care, infection risk and food limits.
- The right choice depends on symptoms, home support, goals and medical risk.
Dialysis Basics
Kidney Support
Dialysis is a treatment for kidney failure. It cleans waste, extra salt and extra fluid from the blood when the kidneys can no longer do enough of that work.
Healthy kidneys work all day and all night, but dialysis works during set treatment times. This means it can help a great deal, while still leaving gaps that healthy kidneys would normally handle every hour (1).
Hemodialysis uses a machine and a filter to clean the blood outside the body. Blood leaves through a tube, passes through the filter and then returns to the body.
Peritoneal dialysis works inside the belly, where the thin lining of the abdomen helps filter waste and extra fluid through a soft tube placed in the belly (2).
Dialysis is usually discussed when kidney failure becomes advanced enough to make blood chemistry unsafe. The decision should include symptoms, fluid overload, blood pressure, potassium, acid levels, appetite, strength and daily function. A lab number can help guide the decision, but the whole picture gives a better view of need and timing (3).
Treatment Choices
Center hemodialysis gives you trained staff during each session. This can feel safer for people who do not want to manage equipment at home. The tradeoff is the schedule, because travel, waiting, treatment and recovery can take much of the day.
Home hemodialysis gives more control over timing for some people. It also needs training, clean space, supplies and a helper in many cases. Some people feel better with longer or more frequent treatment, because fluid and waste can be removed more slowly and more often (1).
Peritoneal dialysis is often done at home. It may give more freedom during the day, especially when the machine runs at night. It also requires careful cleaning, daily attention and strong infection control, because germs can enter through the belly tube and cause a serious infection called peritonitis (2).
Main Benefits
Cleaner Blood
The main benefit of dialysis is simple. It removes waste and extra fluid when kidney failure makes the blood unsafe. Without dialysis or a kidney transplant, advanced kidney failure can become fatal because waste, fluid and minerals can rise beyond what the body can handle (4).
Cleaner blood can change how you feel. Some people have better appetite, more energy and less nausea after treatment starts. Swelling may go down because extra salt and fluid are removed. Breathing may also improve when less fluid is pressing on the lungs and blood vessels (1).
Dialysis also gives your care team regular blood tests and weight checks. Those checks can show whether treatment is removing enough waste and fluid. They can also show when potassium, sodium, phosphate, acid levels or blood pressure need closer attention.
Fluid & Mineral Control
Kidney failure can make the body hold too much fluid. Fluid can collect in the legs, belly, lungs and tissues. This can raise blood pressure and make breathing harder. Dialysis can remove extra water from the blood, which can reduce swelling and help the body feel less overloaded (5).
Mineral shifts can also become dangerous. Potassium can rise when the kidneys cannot clear it well, and high potassium can disturb the heart rhythm. Dialysis can help lower potassium and support safer mineral balance. It can also help manage sodium and other waste products that build up when kidney function falls (5).
More Time
Dialysis can help someone stay alive while waiting for a transplant, or it can become long term treatment when transplant is not chosen or not possible. It may also help a person remain active enough to spend more time with family, continue some work or keep a daily routine.
Dialysis does not repair the kidneys. It also does not replace all kidney work, including hormone signals, constant fluid control and fine mineral control. This is why many people still feel tired or restricted even when treatment is doing its job (4).
Daily Challenges
Time & Energy
Dialysis takes time. Center hemodialysis often means several trips each week, hours in the chair and time to recover afterward. Some people feel drained after treatment because fluid and waste are removed over a short window. The day can become hard to plan because treatment takes the best hours or leaves the body tired.
Home treatments can reduce travel, but they do not remove the workload. Supplies must be stored, machines must be set up and the treatment area must stay clean. Peritoneal dialysis may happen during sleep, but it still requires daily care, tube cleaning and attention to any sign of pain, fever, cloudy fluid or infection.
Fatigue can also come from the disease itself. Kidney failure can affect appetite, sleep, strength, mood and blood chemistry. Dialysis may improve some of these problems, while other problems may remain. This can frustrate people who expected treatment to make them feel normal right away.
Access Problems
Hemodialysis needs a safe way to move blood from the body to the machine and back again. A fistula, graft or catheter can be used. Guidelines often prefer a working fistula when suitable because it can have fewer long term problems than a catheter, but every person needs an access plan based on blood vessels, timing and health status (6).
The skin needs protection. The site needs checks for pain, redness, swelling, bleeding or weak flow. A blocked or infected access can interrupt treatment and may need urgent care. This is one reason early planning is better than a rushed start.
Peritoneal dialysis has a different access burden. The belly catheter must stay clean and secure. Infection prevention becomes serious daily work because peritonitis can cause belly pain, fever and cloudy dialysis fluid. The treatment can work well for many people, but clean technique is not optional (2).
Food
Dialysis often comes with fluid limits. The exact amount depends on urine output, swelling, blood pressure and treatment schedule. Drinking too much can make the next session harder because more fluid must be removed. Fast fluid removal can lead to cramps, low pressure, nausea and heavy tiredness.
Many people need to watch potassium, phosphate, sodium and total fluid. The goal is safer blood chemistry with enough protein and energy to prevent wasting. Whole foods can support protein needs, while processed foods, fortified grain products and packaged meals can add sodium, phosphate additives and poor quality oils.
Some people need stricter potassium control, while others do not. Some need more protein because dialysis can increase protein loss. A kidney trained clinician and renal dietitian can help match food choices to blood tests, treatment type and appetite without turning meals into fear.
Hard Choices
Body Burden
Dialysis can feel like a second job. It asks for time, discipline and repeated medical contact. Some people handle that burden well. Others struggle with exhaustion, pain, sleep loss, low mood, travel problems or the feeling that life revolves around treatment.
The body may also react during sessions. Some people get cramps, headaches, itching, nausea, low blood pressure or heavy fatigue. These problems should be reported because treatment settings, fluid goals, session length and timing may need review.
Home & Family Load
Home dialysis can give more freedom, but it can also move work into the home. A clean space is needed. Supplies take room. A partner or family member may need training. This can help some families feel more in control, while other families may feel stressed by the added work.
Center dialysis can reduce home duties, but travel and fixed schedules create a different burden. Bad weather, transport costs, missed work and long days can wear people down. The best choice is the one that the person can keep doing safely, not the one that sounds best on paper.
Goals Of Care
Some people choose dialysis because they want the longest life possible. Some choose it because they want time with family, a bridge to transplant or relief from severe symptoms.
Some people with heavy illness, frailty or poor quality of life may choose supportive kidney care without dialysis. NIDDK states that some people with kidney failure choose care without dialysis or transplant, while continuing medical care, diet support and symptom care (7).
This choice should be clear and honest. Dialysis can help, but it can also add burden. A good care plan should ask what the person wants most, what treatment can realistically do and what tradeoffs are acceptable. Family support helps, but the person living with kidney failure should remain central in the decision.
For any health concerns or questions about a medical condition, get guidance from a physician or another appropriately trained clinician. Before changing your diet, supplements or health routine, talk with a licensed healthcare professional.
Research
National Institute of Diabetes and Digestive and Kidney Diseases. Hemodialysis. Available at: https://www.niddk.nih.gov/health-information/kidney-disease/kidney-failure/hemodialysis
National Institute of Diabetes and Digestive and Kidney Diseases. Peritoneal Dialysis. Available at: https://www.niddk.nih.gov/health-information/kidney-disease/kidney-failure/peritoneal-dialysis
Chan, C.T. et al. 2019. Dialysis initiation, modality choice, access, and prescription. Kidney International, 96, pp. 37 to 47. Available at: https://kdigo.org/wp-content/uploads/2017/02/KDIGO-Dialysis-Initiation-conf-report-FINAL.pdf
National Kidney Foundation. Dialysis. Available at: https://www.kidney.org/kidney-topics/dialysis
Mayo Clinic. Hemodialysis. Available at: https://www.mayoclinic.org/tests-procedures/hemodialysis/about/pac-20384824
Lok, C.E. et al. 2020. KDOQI Clinical Practice Guideline for Vascular Access. American Journal of Kidney Diseases, 75, S1 to S164. PMID: 32778223. Available at: https://pubmed.ncbi.nlm.nih.gov/32778223/
National Institute of Diabetes and Digestive and Kidney Diseases. What Is Kidney Failure? Available at: https://www.niddk.nih.gov/health-information/kidney-disease/kidney-failure/what-is-kidney-failure
Fletcher, B.R., Damery, S., Aiyegbusi, O.L., Anderson, N., Calvert, M., Cockwell, P., Ferguson, J., Horton, M., Paap, M.C.S., Sidey-Gibbons, C. and Slade, A. (2022) ‘Symptom burden and health-related quality of life in chronic kidney disease: a global systematic review and meta-analysis’, PLOS Medicine, 19(4), e1003954.
Brown, E.A., Zhao, J., McCullough, K., Fuller, D.S., Figueiredo, A.E., Bieber, B., Morgenstern, H., Tentori, F., Jacobson, S.H., Perl, J., Robinson, B.M. and Pisoni, R.L. (2021) ‘Burden of kidney disease, health-related quality of life, and employment among patients receiving peritoneal dialysis and in-center hemodialysis: findings from the DOPPS program’, American Journal of Kidney Diseases, 78(4), pp. 489–500.e1.
NIDDK (2025b) Peritoneal Dialysis. National Institute of Diabetes and Digestive and Kidney Diseases.
Ethier, I., Pei, J., Cho, Y., Hawley, C.M., Johnson, D.W., Campbell, S.B., Francis, R.S., Wong, G., Craig, J.C. and Viecelli, A.K. (2024) ‘Peritoneal dialysis versus haemodialysis for people commencing dialysis’, Cochrane Database of Systematic Reviews, 6, CD013800.
Chuasuwan, A., Pooripussarakul, S., Thakkinstian, A., Ingsathit, A. and Pattanaprateep, O. (2020) ‘Comparisons of quality of life between patients underwent peritoneal dialysis and hemodialysis: a systematic review and meta-analysis’, Health and Quality of Life Outcomes, 18, 191.
Raoofi, S. et al. (2023) ‘Hemodialysis and peritoneal dialysis-health-related quality of life: systematic review plus meta-analysis’, BMJ Supportive & Palliative Care, 13(4), pp. 365–373. doi: 10.1136/bmjspcare-2021-003182. PMID: 34301643.
Lu, Y. et al. (2024) ‘Correlates of symptom burden in renal dialysis patients: a systematic review and meta-analysis’, Renal Failure, 46(2), 2382314. doi: 10.1080/0886022X.2024.2382314. PMID: 39115143.
Murtagh, F.E.M., Addington-Hall, J. and Higginson, I.J. (2007) ‘The prevalence of symptoms in end-stage renal disease: a systematic review’, Advances in Chronic Kidney Disease, 14(1), pp. 82–99. doi: 10.1053/j.ackd.2006.10.001. PMID: 17200048.
Rose, M. et al. (2024) ‘The CONVINCE randomized trial found positive effects on quality of life for patients with chronic kidney disease treated with hemodiafiltration’, Kidney International, 106(5), pp. 961–971. doi: 10.1016/j.kint.2024.07.014. PMID: 39089577.
Korevaar, J.C. et al. (2003) ‘Effect of starting with hemodialysis compared with peritoneal dialysis in patients new on dialysis treatment: a randomized controlled trial’, Kidney International, 64(6), pp. 2222–2228. doi: 10.1046/j.1523-1755.2003.00321.x. PMID: 14633146.
Jung, H.-Y. et al. (2019) ‘Better Quality of Life of Peritoneal Dialysis compared to Hemodialysis over a Two-year Period after Dialysis Initiation’, Scientific Reports, 9(1), 10266. doi: 10.1038/s41598-019-46744-1. PMID: 31312004.
Termorshuizen, F. et al. (2003) ‘Hemodialysis and peritoneal dialysis: comparison of adjusted mortality rates according to the duration of dialysis: analysis of The Netherlands Cooperative Study on the Adequacy of Dialysis 2’, Journal of the American Society of Nephrology, 14(11), pp. 2851–2860. doi: 10.1097/01.ASN.0000091585.45723.9E. PMID: 14569095.
Harris, S.A.C. et al. (2002) ‘Clinical outcomes and quality of life in elderly patients on peritoneal dialysis versus hemodialysis’, Peritoneal Dialysis International, 22(4), pp. 463–470. doi: 10.1177/089686080202200404. PMID: 12322817.
Bakewell, A.B., Higgins, R.M. and Edmunds, M.E. (2002) ‘Quality of life in peritoneal dialysis patients: decline over time and association with clinical outcomes’, Kidney International, 61(1), pp. 239–248. doi: 10.1046/j.1523-1755.2002.00096.x. PMID: 11786106.
Bastos, M.A.P. et al. (2021) ‘Health-related quality of life associated with risk of death in Brazilian dialysis patients: an eight-year cohort’, Quality of Life Research, 30(6), pp. 1595–1604. doi: 10.1007/s11136-020-02734-9. PMID: 33454887.
Griva, K. et al. (2014) ‘Quality of life and emotional distress between patients on peritoneal dialysis versus community-based hemodialysis’, Quality of Life Research, 23(1), pp. 57–66. doi: 10.1007/s11136-013-0431-8. PMID: 23689932.
Al Wakeel, J. et al. (2012) ‘Quality of life in hemodialysis and peritoneal dialysis patients in Saudi Arabia’, Annals of Saudi Medicine, 32(6), pp. 570–574. doi: 10.5144/0256-4947.2012.570. PMID: 23396018.
Almutary, H., Bonner, A. and Douglas, C. (2013) ‘Symptom burden in chronic kidney disease: a review of recent literature’, Journal of Renal Care, 39(3), pp. 140–150. doi: 10.1111/j.1755-6686.2013.12022.x. PMID: 23826803.


